Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.
Lu, Ping; Haagsma, Anna C; Pham, Hoang; Maaskant, Janneke J; Mol, Selena; Lill, Holger; Bald, Dirk.
Antimicrob Agents Chemother
; 55(11): 5354-7, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21876062
'Happy the man, who, studying nature's laws, Thro' known effects can trace the secret cause.' Do we have enough pieces to solve the pyrazinamide puzzle?
Identification of Novel Mutations in LprG (<i>rv1411c</i>), <i>rv0521</i>, <i>rv3630</i>, <i>rv0010c</i>, <i>ppsC</i>, and <i>cyp128</i> Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis.
Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.
Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.
Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.
Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis.
Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis.
Pyrazinoates as antiparasitic agents against Trypanosoma cruzi.
Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.