Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
Basu, Indranil; Locker, Joseph; Cassera, Maria B; Belbin, Thomas J; Merino, Emilio F; Dong, Xinyuan; Hemeon, Ivan; Evans, Gary B; Guha, Chandan; Schramm, Vern L.
J Biol Chem
; 286(6): 4902-11, 2011 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-21135097
Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics.
Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase.
Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.
Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts.
Purine nucleoside phosphorylase activity decline is linked to the decay of the trimeric form of the enzyme.
Mechanism of substrate specificity in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases.
Microbial pathway for anaerobic 5'-methylthioadenosine metabolism coupled to ethylene formation.
Unraveling the structural and functional differences between purine nucleoside phosphorylase and 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus.
Inhibition and structure of Toxoplasma gondii purine nucleoside phosphorylase.
Evidence for purine nucleoside phosphorylase (PNP) release from rat C6 glioma cells.