Modification of CellSensor irf1-bla TF-1 and irf1-bla HEL assays for direct comparison of wild-type JAK2 and JAK2 V617F inhibition.
Mason, Jennifer L; Holskin, Beverly P; Murray, Kristen A; Meyer, Sheryl L; Wells-Knecht, Kevin J; Ator, Mark A; Angeles, Thelma S.
Assay Drug Dev Technol
; 9(3): 311-8, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21133674
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
PGC-1α regulates the expression and activity of IRF-1.
Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk.
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.
An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.
Properties of STAT1 and IRF1 enhancers and the influence of SNPs.
Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery.
Leptin augments recruitment of IRF-1 and CREB to thrombospondin-1 gene promoter in vascular smooth muscle cells in vitro.
Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.