Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.
Zhao, Lianyun; Zhang, Yingxin; Dai, Chaoyang; Guzi, Timothy; Wiswell, Derek; Seghezzi, Wolfgang; Parry, David; Fischmann, Thierry; Siddiqui, M Arshad.
Bioorg Med Chem Lett
; 20(24): 7216-21, 2010 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-21074424
Synthesis, preliminary structure-activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflammatory agents.
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: hit-to-lead optimization.
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[Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo].
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The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors.
Stereoselective tandem synthesis of thiazolo fused naphthyridines and thienopyridines from o-alkynylaldehydes via Au(III)-catalyzed regioselective 6-endo-dig ring closure.
Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors.
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.