Identification of a new biaryl scaffold generating potent renin inhibitors.
Lacombe, Patrick; Aspiotis, Renée; Bayly, Christopher; Chen, Austin; Dubé, Daniel; Fortin, Réjean; Gallant, Michel; Juteau, Hélène; Liu, Suzanna; McKay, Dan; Roy, Patrick; Wu, Tom.
Bioorg Med Chem Lett
; 20(19): 5822-6, 2010 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-20728350
Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.
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New renin inhibitors--stability and activity determination. Part II.
Computational modeling and design of renin inhibitors.
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New renin inhibitors--stability and activity determination. Part I.