Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.
Deenick, Elissa K; Chan, Anna; Ma, Cindy S; Gatto, Dominique; Schwartzberg, Pamela L; Brink, Robert; Tangye, Stuart G.
; 33(2): 241-53, 2010 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-20691615
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases.
Follicular Helper T Cells.
Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity.
Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.
Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.
Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function.
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile.
IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.