Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
He, Peijian; Klein, Janet; Yun, C Chris.
J Biol Chem
; 285(36): 27869-78, 2010 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-20584908
Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3.
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The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.
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