Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors.
Prabhakaran, Jaya; Majo, Vattoly J; Milak, Matthew S; Kassir, Suham A; Palner, Mikael; Savenkova, Lyudmila; Mali, Pratap; Arango, Victoria; Mann, J John; Parsey, Ramin V; Kumar, J S Dileep.
Bioorg Med Chem Lett
; 20(12): 3499-501, 2010 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-20494576
Evaluation of [<sup>18</sup> F]BR420 and [<sup>18</sup> F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer.
Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4).
Straightforward entry to pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones and their ADME properties.
Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors.
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.
Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[<sup>11</sup>C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([<sup>11</sup>C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain.
Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore.