Checkpoints in lymphocyte development and autoimmune disease.
von Boehmer, Harald; Melchers, Fritz.
; 11(1): 14-20, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20016505
N-linked glycosylation selectively regulates autonomous precursor BCR function.
The pre-B cell receptor: turning autoreactivity into self-defense.
The pre-B cell receptor; selecting for or against autoreactivity.
Distorted antibody repertoire developed in the absence of pre-B cell receptor formation.
Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected repertoires.
Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells.
BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.
Self-recognition and clonal selection: autoreactivity drives the generation of B cells.
Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions.
Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells.