Influence of novel CD4 binding-defective HIV-1 envelope glycoprotein immunogens on neutralizing antibody and T-cell responses in nonhuman primates.
Douagi, Iyadh; Forsell, Mattias N E; Sundling, Christopher; O'Dell, Sijy; Feng, Yu; Dosenovic, Pia; Li, Yuxing; Seder, Robert; Loré, Karin; Mascola, John R; Wyatt, Richard T; Karlsson Hedestam, Gunilla B.
; 84(4): 1683-95, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19955308
Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.
Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.
An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.
Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.
Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers.
Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site.
A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.
Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.