Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations.
Okemefuna, Azubuike I; Nan, Ruodan; Miller, Ami; Gor, Jayesh; Perkins, Stephen J.
J Biol Chem
; 285(2): 1053-65, 2010 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-19850925
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces.
Structural basis for engagement by complement factor H of C3b on a self surface.
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