Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.
Errey, James C; Mann, Maretta C; Fairhurst, Shirley A; Hill, Lionel; McNeil, Michael R; Naismith, James H; Percy, Jonathan M; Whitfield, Chris; Field, Robert A.
Org Biomol Chem
; 7(5): 1009-16, 2009 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-19225684
Conformational Control of UDP-Galactopyranose Mutase Inhibition.
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state.
Combined molecular dynamics, STD-NMR, and CORCEMA protocol yields structural model for a UDP-galactopyranose mutase-inhibitor complex.
Molecular Dynamics Simulations of Substrate Release from Trypanosoma cruzi UDP-Galactopyranose Mutase.
Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase.
Identification of novel inhibitors against UDP-galactopyranose mutase to combat leishmaniasis.
The UDP-Galp mutase catalyzed isomerization: synthesis and evaluation of 1,4-anhydro-beta-D-galactopyranose and its [2.2.2] methylene homologue.
A natural protecting group strategy to carry an amino acid starter unit in the biosynthesis of macrolactam polyketide antibiotics.
Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus.
Fragment-based drug discovery using a multidomain, parallel MD-MM/PBSA screening protocol.