Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.
Hayashi, Tomoko; Gray, Christine S; Chan, Michael; Tawatao, Rommel I; Ronacher, Lisa; McGargill, Maureen A; Datta, Sandip K; Carson, Dennis A; Corr, Maripat.
Proc Natl Acad Sci U S A
; 106(8): 2764-9, 2009 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-19188597
Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist.
Treatment with 8-OH-modified adenine (TLR7 ligand)-allergen conjugates decreases T helper type 2-oriented murine airway inflammation.
Guanosine and its modified derivatives are endogenous ligands for TLR7.
Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris suum-induced Allergic Asthma in Nonhuman Primates.
TLR7 tolerance is independent of the type I IFN pathway and leads to loss of anti-tumor efficacy in mice.
C-reactive protein inhibits plasmacytoid dendritic cell interferon responses to autoantibody immune complexes.
Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses.
Synthesis and immunoregulatory activities of conjugates of a Toll-like receptor 7 inert ligand.
Type I IFN-mediated synergistic activation of mouse and human DC subsets by TLR agonists.
Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates.