Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Janoueix-Lerosey, Isabelle; Lequin, Delphine; Brugières, Laurence; Ribeiro, Agnès; de Pontual, Loïc; Combaret, Valérie; Raynal, Virginie; Puisieux, Alain; Schleiermacher, Gudrun; Pierron, Gaëlle; Valteau-Couanet, Dominique; Frebourg, Thierry; Michon, Jean; Lyonnet, Stanislas; Amiel, Jeanne; Delattre, Olivier.
; 455(7215): 967-70, 2008 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-18923523
Identification of ALK as a major familial neuroblastoma predisposition gene.
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
Oncogenic mutations of ALK in neuroblastoma.
Structural basis for the recognition of c-Src by its inactivator Csk.
Oncogenic mutations of ALK kinase in neuroblastoma.
Effect of missense mutations on structure and interaction of anaplastic Lymphoma kinase (ALK) in neuroblastom.
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A secreted tyrosine kinase acts in the extracellular environment.
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