CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection.
Engel, Daniel R; Maurer, Juliane; Tittel, André P; Weisheit, Christina; Cavlar, Taner; Schumak, Beatrix; Limmer, Andreas; van Rooijen, Nico; Trautwein, Christian; Tacke, Frank; Kurts, Christian.
; 181(8): 5579-86, 2008 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-18832716
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice.
Murine macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healing.
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.
CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells.
Binding site characterization of G protein-coupled receptor by alanine-scanning mutagenesis using molecular dynamics and binding free energy approach: application to C-C chemokine receptor-2 (CCR2).
CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.
Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil.
Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2.
Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of <i>Nf1</i> low-grade glioma growth.
Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.