Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.
Nikolskaia, Olga V; de A Lima, Ana Paula C; Kim, Yuri V; Lonsdale-Eccles, John D; Fukuma, Toshihide; Scharfstein, Julio; Grab, Dennis J.
J Clin Invest
; 116(10): 2739-47, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16998589
Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia.
Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter.
Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain.
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei.
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing.
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes.
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.
A single amino acid substitution in the group 1 Trypanosoma brucei gambiense haptoglobin-hemoglobin receptor abolishes TLF-1 binding.