Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.
Bateman, Kevin P; Trimble, Laird; Chauret, Nathalie; Silva, Jose; Day, Stephen; Macdonald, Dwight; Dube, Daniel; Gallant, Michel; Mastracchio, Anthony; Perrier, Helene; Girard, Yves; Nicoll-Griffith, Deborah.
J Mass Spectrom
; 41(6): 771-80, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16705670
Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure.
Discovery of oral and inhaled PDE4 inhibitors.
Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors.
Experimental and mathematical analysis of in vitro Pitavastatin hepatic uptake across species.
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies.
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue.
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.
Identification of in vitro metabolites of a new anticoccidial drug nitromezuril using HepG2 cells, rat S9 and primary hepatocytes by liquid chromatography/tandem mass spectrometry.