4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.
Benjahad, Abdellah; Croisy, Martine; Monneret, Claude; Bisagni, Emile; Mabire, Dominique; Coupa, Sophie; Poncelet, Alain; Csoka, Imre; Guillemont, Jérôme; Meyer, Christophe; Andries, Koen; Pauwels, Rudi; de Béthune, Marie-Pierre; Himmel, Daniel M; Das, Kalyan; Arnold, Eddy; Nguyen, Chi Hung; Grierson, David S.
J Med Chem
; 48(6): 1948-64, 2005 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-15771439
[The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase].
Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities.
Hit optimization studies of 3-hydroxy-indolin-2-one analogs as potential anti-HIV-1 agents.
[The application of structural optimization strategies in drug design of HIV NNRTIs].
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase.
Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.