Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Ghosh, Arun K; Devasamudram, Thippeswamy; Hong, Lin; DeZutter, Christopher; Xu, Xiaoming; Weerasena, Vajira; Koelsch, Gerald; Bilcer, Geoffrey; Tang, Jordan.
Bioorg Med Chem Lett
; 15(1): 15-20, 2005 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-15582402
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Design, synthesis and in vitro evaluation studies of sulfonyl-amino-acetamides as small molecule BACE-1 inhibitors.
Application of Free Energy Perturbation for the Design of BACE1 Inhibitors.
Acquired Removability of Aspartic Protease Inhibitors by Direct Biotinylation.
Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors.
Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors.
Rational design, synthesis and in vitro evaluation of allylidene hydrazinecarboximidamide derivatives as BACE-1 inhibitors.
New Method for Detecting the Suppressing Effect of Enzyme Activity by Aminopeptidase N Inhibitor.
SYNTHESIS AND AMINOPEPTIDASE N INHIBITING ACTIVITY OF 3-(NITROPHENOXYMETHYL)-[1,3,2]DIOXABOROLAN-2-OLS AND THEIR OPEN ANALOGUES.
Fragment-based discovery of BACE1 inhibitors using functional assays.