An efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors.
Mann, Maretta C; Thomson, Robin J; von Itzstein, Mark.
Bioorg Med Chem Lett
; 14(22): 5555-8, 2004 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-15482923
Synthesis of both enantiomers of hydroxypipecolic acid derivatives equivalent to 5-azapyranuronic acids and evaluation of their inhibitory activities against glycosidases.
Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase.
Stereoselective synthesis of 2,3-diamino-2,3-dideoxy-ß-D-mannopyranosyl uronates.
Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase.
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.
Benzylidene Acetal Protecting Group as Carboxylic Acid Surrogate: Synthesis of Functionalized Uronic Acids and Sugar Amino Acids.
Mannosazide methyl uronate donors. Glycosylating properties and use in the construction of ß-ManNAcA-containing oligosaccharides.
Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone.
Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation.
Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of lamotrigine.