Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantation.
Rettig, Michael P; Ritchey, Julie K; Prior, Julie L; Haug, Jeffrey S; Piwnica-Worms, David; DiPersio, John F.
; 173(6): 3620-30, 2004 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-15356106
Implications of Resident Memory T Cells for Transplantation.
T cell CD3Î¶ deficiency enables multiorgan tissue inflammation.
Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice.
A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor ß receptor signaling.
Tbet is a critical modulator of FoxP3 expression in autoimmune graft-<i>versus</i>-host disease.
Donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene: detailed immunological function following add-back after haplo-identical transplantation.
Donor lymphocyte infusion leads to diversity of specific T cell responses and reduces regulatory T cell frequency in clinical responders.
Identification of tonsillar CD4<sup>+</sup>CD25<sup>-</sup>LAG3<sup>+</sup> T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue.
GVHD pathophysiology: is acute different from chronic?
Memory T cell subsets, migration patterns, and tissue residence.