3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Benjahad, Abdellah; Guillemont, Jérôme; Andries, Koen; Nguyen, Chi Hung; Grierson, David S.
Bioorg Med Chem Lett
; 13(24): 4309-12, 2003 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-14643315
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.
A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(2H)-ones as potency inhibitors of HIV-1 variants.
Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.
Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds.
Synthesis of pentacyclic iminosugars with constrained butterfly-like conformation and their HIV-RT inhibitory activity.
Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs.
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Highly efficient synthesis of HIV NNRTI doravirine.
Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.