Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
Turner, Robert T; Loy, Jeffrey A; Nguyen, Chan; Devasamudram, Thippeswamy; Ghosh, Arun K; Koelsch, Gerald; Tang, Jordan.
; 41(27): 8742-6, 2002 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-12093293
pH-Dependent Population Shift Regulates BACE1 Activity and Inhibition.
Effect of sampling on BACE-1 ligands binding free energy predictions via MM-PBSA calculations.
Molecular insights into the inhibitory mechanism of bi-functional bis-tryptoline triazole against ß-secretase (BACE1) enzyme.
Modulation of BACE1 Activity by Chemically Modified Aptamers.
BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology.
Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors of ß-secretase (BACE1).
Computational Modeling of ß-Secretase 1 (BACE-1) Inhibitors Using Ligand Based Approaches.
Methyl-substitution of an iminohydantoin spiropiperidine ß-secretase (BACE-1) inhibitor has a profound effect on its potency.
Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum.
Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease.