Antibody recognition of a conformational epitope in a peptide antigen: Fv-peptide complex of an antibody fragment specific for the mutant EGF receptor, EGFRvIII.
Landry, R C; Klimowicz, A C; Lavictoire, S J; Borisova, S; Kottachchi, D T; Lorimer, I A; Evans, S V.
J Mol Biol
; 308(5): 883-93, 2001 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-11352579
Immunogenicity of therapeutic recombinant immunotoxins.
Establishment of Neurospora crassa as a host for heterologous protein production using a human antibody fragment as a model product.
Single-chain antibodies as diagnostic tools and therapeutic agents.
A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sections.
Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation.
Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia.
Designing cell-targeted therapeutic proteins reveals the interplay between domain connectivity and cell binding.
Production and binding analyses of a humanised scFv against a cryptic epitope on tumour-associated fibronectin.
Deimmunizing substitutions in <i>Pseudomonas</i> exotoxin domain III perturb antigen processing without eliminating T-cell epitopes.
Rational affinity enhancement of fragmented antibody by ligand-based affinity improvement approach.