Pesquisa | Biblioteca Virtual em Saúde

1.

Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis.

Zhou, Changyang; Sun, Yidi; Yan, Rui; Liu, Yajing; Zuo, Erwei; Gu, Chan; Han, Linxiao; Wei, Yu; Hu, Xinde; Zeng, Rong; Li, Yixue; Zhou, Haibo; Guo, Fan; Yang, Hui.

Nature; 571(7764): 275-278, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31181567

2.

Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing.

Zhang, He; Pan, Hong; Zhou, Changyang; Wei, Yu; Ying, Wenqin; Li, Shuting; Wang, Guangqin; Li, Chao; Ren, Yifei; Li, Gen; Ding, Xu; Sun, Yidi; Li, Geng-Lin; Song, Lei; Li, Yixue; Yang, Hui; Liu, Zhiyong.

Development; 145(20)2018 Oct 17.

Artigo em Inglês | MEDLINE | ID: mdl-30275281

3.

Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development.

Yang, Guang; Zhou, Changyang; Wang, Ran; Huang, Shisheng; Wei, Yu; Yang, Xianfa; Liu, Yajing; Li, Jianan; Lu, Zongyang; Ying, Wenqin; Li, Xiajun; Jing, Naihe; Huang, Xingxu; Yang, Hui; Qiao, Yunbo.

Cell Rep; 26(2): 302-312.e4, 2019 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-30625312

4.

Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors.

Zhang, Meiling; Zhou, Changyang; Wei, Yu; Xu, Chunlong; Pan, Hong; Ying, Wenqin; Sun, Yidi; Sun, Yun; Xiao, Qingquan; Yao, Ning; Zhong, Wanxia; Li, Yun; Wu, Keliang; Yuan, Gao; Mitalipov, Shoukhrat; Chen, Zi-Jiang; Yang, Hui.

Genome Biol; 20(1): 101, 2019 05 22.

Artigo em Inglês | MEDLINE | ID: mdl-31118069

5.

In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.

Zhou, Haibo; Liu, Junlai; Zhou, Changyang; Gao, Ni; Rao, Zhiping; Li, He; Hu, Xinde; Li, Changlin; Yao, Xuan; Shen, Xiaowen; Sun, Yidi; Wei, Yu; Liu, Fei; Ying, Wenqin; Zhang, Junming; Tang, Cheng; Zhang, Xu; Xu, Huatai; Shi, Linyu; Cheng, Leping; Huang, Pengyu; Yang, Hui.

Nat Neurosci; 21(3): 440-446, 2018 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-29335603

6.

One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.

Zuo, Erwei; Cai, Yi-Jun; Li, Kui; Wei, Yu; Wang, Bang-An; Sun, Yidi; Liu, Zhen; Liu, Jiwei; Hu, Xinde; Wei, Wei; Huo, Xiaona; Shi, Linyu; Tang, Cheng; Liang, Dan; Wang, Yan; Nie, Yan-Hong; Zhang, Chen-Chen; Yao, Xuan; Wang, Xing; Zhou, Changyang; Ying, Wenqin; Wang, Qifang; Chen, Ren-Chao; Shen, Qi; Xu, Guo-Liang; Li, Jinsong; Sun, Qiang; Xiong, Zhi-Qi; Yang, Hui.

Cell Res; 27(7): 933-945, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28585534

7.

Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL60 cells.

Liu, Ya-Jing; Zhou, Chang-Yang; Qiu, Chun-Hong; Lu, Xiu-Min; Wang, Yong-Tang.

Mol Med Rep; 8(4): 1106-10, 2013 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-23982123

8.

Highly efficient base editing in human tripronuclear zygotes.

Zhou, Changyang; Zhang, Meiling; Wei, Yu; Sun, Yidi; Sun, Yun; Pan, Hong; Yao, Ning; Zhong, Wanxia; Li, Yixue; Li, Weiping; Yang, Hui; Chen, Zi-Jiang.

Protein Cell; 8(10): 772-775, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28875305

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