Pesquisa | Biblioteca Virtual em Saúde

1.

Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori.

Paraskevopoulou, Vasiliki; Artiaga, Verónica García; Rowlinson, Rachel; Winkler, G Sebastiaan; Gellert, Paul; Stolnik, Snow; Overman, Ross; Falcone, Franco H.

Protein Expr Purif; 163: 105446, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31271862

2.

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.

Maryati, Maryati; Airhihen, Blessing; Winkler, G Sebastiaan.

Biochem J; 469(1): 169-76, 2015 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-25944446

3.

A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity.

Maryati, Maryati; Kaur, Ishwinder; Jadhav, Gopal P; Olotu-Umoren, Loyin; Oveh, Blessing; Hashmi, Lubna; Fischer, Peter M; Winkler, G Sebastiaan.

Nucleic Acids Res; 42(5): e30, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24170810

4.

Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag.

Hage, Naim; Renshaw, Jonathan G; Winkler, G Sebastiaan; Gellert, Paul; Stolnik, Snow; Falcone, Franco H.

Protein Expr Purif; 106: 25-30, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25448827

5.

Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown.

Loczenski Rose, Vanessa; Shubber, Saif; Sajeesh, S; Spain, Sebastian G; Puri, Sanyogitta; Allen, Stephanie; Lee, Dong-Ki; Winkler, G Sebastiaan; Mantovani, Giuseppe.

Biomacromolecules; 16(11): 3480-90, 2015 Nov 09.

Artigo em Inglês | MEDLINE | ID: mdl-26397811

6.

Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.

Jadhav, Gopal P; Kaur, Ishwinder; Maryati, Maryati; Airhihen, Blessing; Fischer, Peter M; Winkler, G Sebastiaan.

Bioorg Med Chem Lett; 25(19): 4219-24, 2015 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-26299350

7.

RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes.

Wahle, Elmar; Winkler, G Sebastiaan.

Biochim Biophys Acta; 1829(6-7): 561-70, 2013 Jun-Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23337855

8.

Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.

Collins, Hilary M; Abdelghany, Magdy K; Messmer, Marie; Yue, Baigong; Deeves, Sian E; Kindle, Karin B; Mantelingu, Kempegowda; Aslam, Akhmed; Winkler, G Sebastiaan; Kundu, Tapas K; Heery, David M.

BMC Cancer; 13: 37, 2013 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-23356739

9.

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex.

Doidge, Rachel; Mittal, Saloni; Aslam, Akhmed; Winkler, G Sebastiaan.

Biochem Soc Trans; 40(4): 896-901, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-22817755

10.

The mammalian anti-proliferative BTG/Tob protein family.

Winkler, G Sebastiaan.

J Cell Physiol; 222(1): 66-72, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19746446

11.

An Integrated Dyspepsia Module for First-year Pharmacy Students.

De Matteis, Cristina I; Randall, Michael D; Harvey, Eleanor J; Morris, Andrew; Winkler, G Sebastiaan; Boardman, Helen F.

Am J Pharm Educ; 83(1): 6508, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30894766

12.

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.

Mulder, Klaas W; Inagaki, Akiko; Cameroni, Elisabetta; Mousson, Florence; Winkler, G Sebastiaan; De Virgilio, Claudio; Collart, Martine A; Timmers, H Th Marc.

Genetics; 176(1): 181-92, 2007 May.

Artigo em Inglês | MEDLINE | ID: mdl-17513889

13.

Menin links estrogen receptor activation to histone H3K4 trimethylation.

Dreijerink, Koen M A; Mulder, Klaas W; Winkler, G Sebastiaan; Höppener, Jo W M; Lips, Cornelis J M; Timmers, H Th Marc.

Cancer Res; 66(9): 4929-35, 2006 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-16651450

14.

DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.

Mulder, Klaas W; Winkler, G Sebastiaan; Timmers, H Th Marc.

Nucleic Acids Res; 33(19): 6384-92, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-16275785

15.

Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches.

Dominguez, Cyril; Bonvin, Alexandre M J J; Winkler, G Sebastiaan; van Schaik, Frederik M A; Timmers, H Th Marc; Boelens, Rolf.

Structure; 12(4): 633-44, 2004 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15062086

16.

Structure-based approaches to create new E2-E3 enzyme pairs.

Winkler, G Sebastiaan; Timmers, H Th Marc.

Methods Enzymol; 399: 355-66, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-16338368

17.

An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.

Winkler, G Sebastiaan; Albert, Thomas K; Dominguez, Cyril; Legtenberg, Yvonne I A; Boelens, Rolf; Timmers, H Th Marc.

J Mol Biol; 337(1): 157-65, 2004 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-15001359

18.

Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

Hage, Naim; Howard, Tina; Phillips, Chris; Brassington, Claire; Overman, Ross; Debreczeni, Judit; Gellert, Paul; Stolnik, Snow; Winkler, G Sebastiaan; Falcone, Franco H.

Sci Adv; 1(7): e1500315, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26601230

19.

Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex.

Winkler, G Sebastiaan; Balacco, Dario L.

Front Genet; 4: 296, 2013 Dec 23.

Artigo em Inglês | MEDLINE | ID: mdl-24391663

20.

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.