Pesquisa | Biblioteca Virtual em Saúde

1.

The cell-cycle state of stem cells determines cell fate propensity.

Pauklin, Siim; Vallier, Ludovic.

Cell; 155(1): 135-47, 2013 Sep 26.

Artigo em Inglês | MEDLINE | ID: mdl-24074866

2.

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.

Yusa, Kosuke; Rashid, S Tamir; Strick-Marchand, Helene; Varela, Ignacio; Liu, Pei-Qi; Paschon, David E; Miranda, Elena; Ordóñez, Adriana; Hannan, Nicholas R F; Rouhani, Foad J; Darche, Sylvie; Alexander, Graeme; Marciniak, Stefan J; Fusaki, Noemi; Hasegawa, Mamoru; Holmes, Michael C; Di Santo, James P; Lomas, David A; Bradley, Allan; Vallier, Ludovic.

Nature; 478(7369): 391-4, 2011 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-21993621

3.

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Gieseck, Richard L; Ramalingam, Thirumalai R; Hart, Kevin M; Vannella, Kevin M; Cantu, David A; Lu, Wei-Yu; Ferreira-González, Sofía; Forbes, Stuart J; Vallier, Ludovic; Wynn, Thomas A.

Immunity; 45(1): 145-58, 2016 07 19.

Artigo em Inglês | MEDLINE | ID: mdl-27421703

4.

The Cell-Cycle State of Stem Cells Determines Cell Fate Propensity.

Pauklin, Siim; Vallier, Ludovic.

Cell; 156(6): 1338, 2014 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-28898638

5.

The SMAD2/3 interactome reveals that TGFß controls m⁶A mRNA methylation in pluripotency.

Bertero, Alessandro; Brown, Stephanie; Madrigal, Pedro; Osnato, Anna; Ortmann, Daniel; Yiangou, Loukia; Kadiwala, Juned; Hubner, Nina C; de Los Mozos, Igor Ruiz; Sadée, Christoph; Lenaerts, An-Sofie; Nakanoh, Shota; Grandy, Rodrigo; Farnell, Edward; Ule, Jernej; Stunnenberg, Hendrik G; Mendjan, Sasha; Vallier, Ludovic.

Nature; 555(7695): 256-259, 2018 03 08.

Artigo em Inglês | MEDLINE | ID: mdl-29489750

6.

Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D.

Pauklin, Siim; Madrigal, Pedro; Bertero, Alessandro; Vallier, Ludovic.

Genes Dev; 30(4): 421-33, 2016 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-26883361

7.

Genome editing reveals a role for OCT4 in human embryogenesis.

Fogarty, Norah M E; McCarthy, Afshan; Snijders, Kirsten E; Powell, Benjamin E; Kubikova, Nada; Blakeley, Paul; Lea, Rebecca; Elder, Kay; Wamaitha, Sissy E; Kim, Daesik; Maciulyte, Valdone; Kleinjung, Jens; Kim, Jin-Soo; Wells, Dagan; Vallier, Ludovic; Bertero, Alessandro; Turner, James M A; Niakan, Kathy K.

Nature; 550(7674): 67-73, 2017 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-28953884

8.

Erratum: Genome editing reveals a role for OCT4 in human embryogenesis.

Fogarty, Norah M E; McCarthy, Afshan; Snijders, Kirsten E; Powell, Benjamin E; Kubikova, Nada; Blakeley, Paul; Lea, Rebecca; Elder, Kay; Wamaitha, Sissy E; Kim, Daesik; Maciulyte, Valdone; Kleinjung, Jens; Kim, Jin-Soo; Wells, Dagan; Vallier, Ludovic; Bertero, Alessandro; Turner, James M A; Niakan, Kathy K.

Nature; 551(7679): 256, 2017 11 09.

Artigo em Inglês | MEDLINE | ID: mdl-28976971

9.

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen, Helena; Goncalves, Angela; Leha, Andreas; Afzal, Vackar; Alasoo, Kaur; Ashford, Sofie; Bala, Sendu; Bensaddek, Dalila; Casale, Francesco Paolo; Culley, Oliver J; Danecek, Petr; Faulconbridge, Adam; Harrison, Peter W; Kathuria, Annie; McCarthy, Davis; McCarthy, Shane A; Meleckyte, Ruta; Memari, Yasin; Moens, Nathalie; Soares, Filipa; Mann, Alice; Streeter, Ian; Agu, Chukwuma A; Alderton, Alex; Nelson, Rachel; Harper, Sarah; Patel, Minal; White, Alistair; Patel, Sharad R; Clarke, Laura; Halai, Reena; Kirton, Christopher M; Kolb-Kokocinski, Anja; Beales, Philip; Birney, Ewan; Danovi, Davide; Lamond, Angus I; Ouwehand, Willem H; Vallier, Ludovic; Watt, Fiona M; Durbin, Richard; Stegle, Oliver; Gaffney, Daniel J.

Nature; 546(7660): 686, 2017 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-28614302

10.

Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen, Helena; Goncalves, Angela; Leha, Andreas; Afzal, Vackar; Alasoo, Kaur; Ashford, Sofie; Bala, Sendu; Bensaddek, Dalila; Casale, Francesco Paolo; Culley, Oliver J; Danecek, Petr; Faulconbridge, Adam; Harrison, Peter W; Kathuria, Annie; McCarthy, Davis; McCarthy, Shane A; Meleckyte, Ruta; Memari, Yasin; Moens, Nathalie; Soares, Filipa; Mann, Alice; Streeter, Ian; Agu, Chukwuma A; Alderton, Alex; Nelson, Rachel; Harper, Sarah; Patel, Minal; White, Alistair; Patel, Sharad R; Clarke, Laura; Halai, Reena; Kirton, Christopher M; Kolb-Kokocinski, Anja; Beales, Philip; Birney, Ewan; Danovi, Davide; Lamond, Angus I; Ouwehand, Willem H; Vallier, Ludovic; Watt, Fiona M; Durbin, Richard; Stegle, Oliver; Gaffney, Daniel J.

Nature; 546(7658): 370-375, 2017 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-28489815

11.

Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.

Bertero, Alessandro; Madrigal, Pedro; Galli, Antonella; Hubner, Nina C; Moreno, Inmaculada; Burks, Deborah; Brown, Stephanie; Pedersen, Roger A; Gaffney, Daniel; Mendjan, Sasha; Pauklin, Siim; Vallier, Ludovic.

Genes Dev; 29(7): 702-17, 2015 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-25805847

12.

Cell cycle regulators control mesoderm specification in human pluripotent stem cells.

Yiangou, Loukia; Grandy, Rodrigo A; Osnato, Anna; Ortmann, Daniel; Sinha, Sanjay; Vallier, Ludovic.

J Biol Chem; 294(47): 17903-17914, 2019 Nov 22.

Artigo em Inglês | MEDLINE | ID: mdl-31515269

13.

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.

Bertero, Alessandro; Pawlowski, Matthias; Ortmann, Daniel; Snijders, Kirsten; Yiangou, Loukia; Cardoso de Brito, Miguel; Brown, Stephanie; Bernard, William G; Cooper, James D; Giacomelli, Elisa; Gambardella, Laure; Hannan, Nicholas R F; Iyer, Dharini; Sampaziotis, Fotios; Serrano, Felipe; Zonneveld, Mariëlle C F; Sinha, Sanjay; Kotter, Mark; Vallier, Ludovic.

Development; 143(23): 4405-4418, 2016 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-27899508

14.

Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.

Fourrier, Angélique; Delbos, Frédéric; Menoret, Séverine; Collet, Camille; Thi Thuy, Linh Trinh; Myara, Anne; Petit, François; Tolosa, Laia; Laplanche, Sophie; Gómez-Lechón, María José; Labrune, Philippe; Anegon, Ignacio; Vallier, Ludovic; Garnier, Delphine; Nguyen, Tuan Huy.

Xenotransplantation; : e12544, 2019 Jul 25.

Artigo em Inglês | MEDLINE | ID: mdl-31342573

15.

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

Rouhani, Foad J; Nik-Zainal, Serena; Wuster, Arthur; Li, Yilong; Conte, Nathalie; Koike-Yusa, Hiroko; Kumasaka, Natsuhiko; Vallier, Ludovic; Yusa, Kosuke; Bradley, Allan.

PLoS Genet; 12(4): e1005932, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-27054363

16.

Pluripotency factors regulate definitive endoderm specification through eomesodermin.

Teo, Adrian Kee Keong; Arnold, Sebastian J; Trotter, Matthew W B; Brown, Stephanie; Ang, Lay Teng; Chng, Zhenzhi; Robertson, Elizabeth J; Dunn, N Ray; Vallier, Ludovic.

Genes Dev; 25(3): 238-50, 2011 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-21245162

17.

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α₁-antitrypsin deficiency.

Segeritz, Charis-Patricia; Rashid, Sheikh Tamir; de Brito, Miguel Cardoso; Serra, Maria Paola; Ordonez, Adriana; Morell, Carola Maria; Kaserman, Joseph E; Madrigal, Pedro; Hannan, Nicholas R F; Gatto, Laurent; Tan, Lu; Wilson, Andrew A; Lilley, Kathryn; Marciniak, Stefan J; Gooptu, Bibek; Lomas, David A; Vallier, Ludovic.

J Hepatol; 69(4): 851-860, 2018 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-29879455

18.

Activin/Nodal signalling in stem cells.

Pauklin, Siim; Vallier, Ludovic.

Development; 142(4): 607-19, 2015 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-25670788

19.

Advances in the generation of bioengineered bile ducts.

Justin, Alexander W; Saeb-Parsy, Kourosh; Markaki, Athina E; Vallier, Ludovic; Sampaziotis, Fotios.

Biochim Biophys Acta Mol Basis Dis; 1864(4 Pt B): 1532-1538, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29097260

20.

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

Rashidi, Hassan; Luu, Nguyet-Thin; Alwahsh, Salamah M; Ginai, Maaria; Alhaque, Sharmin; Dong, Hua; Tomaz, Rute A; Vernay, Bertrand; Vigneswara, Vasanthy; Hallett, John M; Chandrashekran, Anil; Dhawan, Anil; Vallier, Ludovic; Bradley, Mark; Callanan, Anthony; Forbes, Stuart J; Newsome, Philip N; Hay, David C.

Arch Toxicol; 92(10): 3117-3129, 2018 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-30155720

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The cell-cycle state of stem cells determines cell fate propensity.

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

The Cell-Cycle State of Stem Cells Determines Cell Fate Propensity.

The SMAD2/3 interactome reveals that TGFß controls m⁶A mRNA methylation in pluripotency.

Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D.

Genome editing reveals a role for OCT4 in human embryogenesis.

Erratum: Genome editing reveals a role for OCT4 in human embryogenesis.

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs.

Common genetic variation drives molecular heterogeneity in human iPSCs.

Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.

Cell cycle regulators control mesoderm specification in human pluripotent stem cells.

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.

Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

Pluripotency factors regulate definitive endoderm specification through eomesodermin.

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α₁-antitrypsin deficiency.

Activin/Nodal signalling in stem cells.

Advances in the generation of bioengineered bile ducts.

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.