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1.
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.
Hum Mol Genet;
18(18): 3452-61, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19549636
2.
Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome.
Kidney Int;
78(8): 782-8, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20703214
3.
FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.
J Immunol;
199(1): 292-303, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533443
4.
Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis.
J Immunol;
199(3): 1021-1040, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28652401
5.
Factor H Competitor Generated by Gene Conversion Events Associates with Atypical Hemolytic Uremic Syndrome.
J Am Soc Nephrol;
29(1): 240-249, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28993505
6.
Complete functional characterization of disease-associated genetic variants in the complement factor H gene.
Kidney Int;
93(2): 470-481, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28941939
7.
Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.
Eur J Immunol;
47(3): 504-515, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28083930
8.
Factor H-related proteins determine complement-activating surfaces.
Trends Immunol;
36(6): 374-84, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25979655
9.
Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy.
Kidney Int;
92(4): 953-963, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28637589
10.
Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases.
J Am Soc Nephrol;
27(5): 1305-11, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26376859
11.
A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.
J Immunol;
193(11): 5567-75, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25355917
12.
Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.
Proc Natl Acad Sci U S A;
110(33): 13504-9, 2013 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23901101
13.
A novel atypical hemolytic uremic syndrome-associated hybrid CFHR1/CFH gene encoding a fusion protein that antagonizes factor H-dependent complement regulation.
J Am Soc Nephrol;
26(1): 209-19, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24904082
14.
Genetics of atypical hemolytic uremic syndrome (aHUS).
Semin Thromb Hemost;
40(4): 422-30, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24799305
15.
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.
J Immunol;
189(4): 1858-67, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22786770
16.
Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance.
Kidney Int;
81(1): 56-63, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21881555
17.
3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.
Proc Natl Acad Sci U S A;
106(3): 882-7, 2009 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19136636
18.
Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B.
Proc Natl Acad Sci U S A;
106(11): 4366-71, 2009 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19255449
19.
Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase.
J Immunol;
183(11): 7347-51, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19890040
20.
The role of complement in IgA nephropathy.
Mol Immunol;
114: 123-132, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31351413