Pesquisa | Biblioteca Virtual em Saúde

1.

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.

Heinig, Matthias; Petretto, Enrico; Wallace, Chris; Bottolo, Leonardo; Rotival, Maxime; Lu, Han; Li, Yoyo; Sarwar, Rizwan; Langley, Sarah R; Bauerfeind, Anja; Hummel, Oliver; Lee, Young-Ae; Paskas, Svetlana; Rintisch, Carola; Saar, Kathrin; Cooper, Jason; Buchan, Rachel; Gray, Elizabeth E; Cyster, Jason G; Erdmann, Jeanette; Hengstenberg, Christian; Maouche, Seraya; Ouwehand, Willem H; Rice, Catherine M; Samani, Nilesh J; Schunkert, Heribert; Goodall, Alison H; Schulz, Herbert; Roider, Helge G; Vingron, Martin; Blankenberg, Stefan; Münzel, Thomas; Zeller, Tanja; Szymczak, Silke; Ziegler, Andreas; Tiret, Laurence; Smyth, Deborah J; Pravenec, Michal; Aitman, Timothy J; Cambien, Francois; Clayton, David; Todd, John A; Hubner, Norbert; Cook, Stuart A.

Nature; 467(7314): 460-4, 2010 Sep 23.

Artigo em Inglês | MEDLINE | ID: mdl-20827270

2.

Genomewide association analysis of coronary artery disease.

Samani, Nilesh J; Erdmann, Jeanette; Hall, Alistair S; Hengstenberg, Christian; Mangino, Massimo; Mayer, Bjoern; Dixon, Richard J; Meitinger, Thomas; Braund, Peter; Wichmann, H-Erich; Barrett, Jennifer H; König, Inke R; Stevens, Suzanne E; Szymczak, Silke; Tregouet, David-Alexandre; Iles, Mark M; Pahlke, Friedrich; Pollard, Helen; Lieb, Wolfgang; Cambien, Francois; Fischer, Marcus; Ouwehand, Willem; Blankenberg, Stefan; Balmforth, Anthony J; Baessler, Andrea; Ball, Stephen G; Strom, Tim M; Braenne, Ingrid; Gieger, Christian; Deloukas, Panos; Tobin, Martin D; Ziegler, Andreas; Thompson, John R; Schunkert, Heribert.

N Engl J Med; 357(5): 443-53, 2007 Aug 02.

Artigo em Inglês | MEDLINE | ID: mdl-17634449

3.

Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases.

Aden, Konrad; Rehman, Ateequr; Waschina, Silvio; Pan, Wei-Hung; Walker, Alesia; Lucio, Marianna; Nunez, Alejandro Mena; Bharti, Richa; Zimmerman, Johannes; Bethge, Johannes; Schulte, Berenice; Schulte, Dominik; Franke, Andre; Nikolaus, Susanna; Schroeder, Johann Oltmann; Vandeputte, Doris; Raes, Jeroen; Szymczak, Silke; Waetzig, Georg H; Zeuner, Rainald; Schmitt-Kopplin, Philippe; Kaleta, Christoph; Schreiber, Stefan; Rosenstiel, Philip.

Gastroenterology; 157(5): 1279-1292.e11, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31326413

4.

Surrogate minimal depth as an importance measure for variables in random forests.

Seifert, Stephan; Gundlach, Sven; Szymczak, Silke.

Bioinformatics; 35(19): 3663-3671, 2019 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-30824905

5.

The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus.

Schlicht, Kristina; Nyczka, Piotr; Caliebe, Amke; Freitag-Wolf, Sandra; Claringbould, Annique; Franke, Lude; Võsa, Urmo; Kardia, Sharon L R; Smith, Jennifer A; Zhao, Wei; Gieger, Christian; Peters, Annette; Prokisch, Holger; Strauch, Konstantin; Baurecht, Hansjörg; Weidinger, Stephan; Rosenstiel, Philip; Hütt, Marc-Thorsten; Knecht, Carolin; Szymczak, Silke; Krawczak, Michael.

Hum Genet; 138(4): 375-388, 2019 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-30852652

6.

Evaluation of variable selection methods for random forests and omics data sets.

Degenhardt, Frauke; Seifert, Stephan; Szymczak, Silke.

Brief Bioinform; 2017 Oct 16.

Artigo em Inglês | MEDLINE | ID: mdl-29045534

7.

Genome-wide association study of serum coenzyme Q10 levels identifies susceptibility loci linked to neuronal diseases.

Degenhardt, Frauke; Niklowitz, Petra; Szymczak, Silke; Jacobs, Gunnar; Lieb, Wolfgang; Menke, Thomas; Laudes, Matthias; Esko, Tõnu; Weidinger, Stephan; Franke, Andre; Döring, Frank; Onur, Simone.

Hum Mol Genet; 25(13): 2881-2891, 2016 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-27149984

8.

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases.

Nikolaus, Susanna; Schulte, Berenice; Al-Massad, Natalie; Thieme, Florian; Schulte, Dominik M; Bethge, Johannes; Rehman, Ateequr; Tran, Florian; Aden, Konrad; Häsler, Robert; Moll, Natalie; Schütze, Gregor; Schwarz, Markus J; Waetzig, Georg H; Rosenstiel, Philip; Krawczak, Michael; Szymczak, Silke; Schreiber, Stefan.

Gastroenterology; 153(6): 1504-1516.e2, 2017 12.

Artigo em Inglês | MEDLINE | ID: mdl-28827067

9.

Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases.

Nikolaus, Susanna; Waetzig, Georg H; Butzin, Sven; Ziolkiewicz, Monika; Al-Massad, Natalie; Thieme, Florian; Lövgren, Ulf; Rasmussen, Birgitte B; Reinheimer, Torsten M; Seegert, Dirk; Rosenstiel, Philip; Szymczak, Silke; Schreiber, Stefan.

Int J Colorectal Dis; 33(7): 927-936, 2018 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-29748708

10.

A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase.

Sei, Yoshitatsu; Zhao, Xilin; Forbes, Joanne; Szymczak, Silke; Li, Qing; Trivedi, Apurva; Voellinger, Mark; Joy, Grishma; Feng, Jianying; Whatley, Millie; Jones, MaryPat Sussex; Harper, Ursula L; Marx, Stephen J; Venkatesan, Aradhana M; Chandrasekharappa, Settara C; Raffeld, Mark; Quezado, Martha M; Louie, Adeline; Chen, Clara C; Lim, Ramona M; Agarwala, Richa; Schäffer, Alejandro A; Hughes, Marybeth S; Bailey-Wilson, Joan E; Wank, Stephen A.

Gastroenterology; 149(1): 67-78, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-25865046

11.

Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity.

Reuther, Sebastian; Szymczak, Silke; Raabe, Annette; Borgmann, Kerstin; Ziegler, Andreas; Petersen, Cordula; Dikomey, Ekkehard; Hoeller, Ulrike.

Strahlenther Onkol; 191(1): 59-66, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25156511

12.

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.

Rotival, Maxime; Zeller, Tanja; Wild, Philipp S; Maouche, Seraya; Szymczak, Silke; Schillert, Arne; Castagné, Raphaele; Deiseroth, Arne; Proust, Carole; Brocheton, Jessy; Godefroy, Tiphaine; Perret, Claire; Germain, Marine; Eleftheriadis, Medea; Sinning, Christoph R; Schnabel, Renate B; Lubos, Edith; Lackner, Karl J; Rossmann, Heidi; Münzel, Thomas; Rendon, Augusto; Erdmann, Jeanette; Deloukas, Panos; Hengstenberg, Christian; Diemert, Patrick; Montalescot, Gilles; Ouwehand, Willem H; Samani, Nilesh J; Schunkert, Heribert; Tregouet, David-Alexandre; Ziegler, Andreas; Goodall, Alison H; Cambien, François; Tiret, Laurence; Blankenberg, Stefan.

PLoS Genet; 7(12): e1002367, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-22144904

13.

Adaptive linear rank tests for eQTL studies.

Szymczak, Silke; Scheinhardt, Markus O; Zeller, Tanja; Wild, Philipp S; Blankenberg, Stefan; Ziegler, Andreas.

Stat Med; 32(3): 524-37, 2013 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-22933317

14.

Protein profiling of genomic instability in endometrial cancer.

Gemoll, Timo; Habermann, Jens K; Lahmann, Johanna; Szymczak, Silke; Lundgren, Caroline; Bündgen, Nana K; Jungbluth, Thomas; Nordström, Britta; Becker, Susanne; Lomnytska, Marta I; Bruch, Hans-Peter; Ziegler, Andreas; Hellman, Ulf; Auer, Gert; Roblick, Uwe J; Jörnvall, Hans.

Cell Mol Life Sci; 69(2): 325-33, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21739232

15.

HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers.

Gemoll, Timo; Roblick, Uwe J; Szymczak, Silke; Braunschweig, Till; Becker, Susanne; Igl, Bernd-Wolfgang; Bruch, Hans-Peter; Ziegler, Andreas; Hellman, Ulf; Difilippantonio, Michael J; Ried, Thomas; Jörnvall, Hans; Auer, Gert; Habermann, Jens K.

Cell Mol Life Sci; 68(19): 3261-74, 2011 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-21290163

16.

Influence of sex and genetic variability on expression of X-linked genes in human monocytes.

Castagné, Raphaële; Zeller, Tanja; Rotival, Maxime; Szymczak, Silke; Truong, Vinh; Schillert, Arne; Trégouët, David-Alexandre; Münzel, Thomas; Ziegler, Andreas; Cambien, François; Blankenberg, Stefan; Tiret, Laurence.

Genomics; 98(5): 320-6, 2011 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-21763416

17.

Machine learning in genome-wide association studies.

Szymczak, Silke; Biernacka, Joanna M; Cordell, Heather J; González-Recio, Oscar; König, Inke R; Zhang, Heping; Sun, Yan V.

Genet Epidemiol; 33 Suppl 1: S51-7, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19924717

18.

Heterogeneous intracellular TRAIL-receptor distribution predicts poor outcome in breast cancer patients.

Heilmann, Thorsten; Vondung, Florian; Borzikowsky, Christoph; Szymczak, Silke; Krüger, Sandra; Alkatout, Ibrahim; Wenners, Antonia; Bauer, Maret; Klapper, Wolfram; Röcken, Christoph; Maass, Nicolai; von Karstedt, Silvia; Schem, Christian; Trauzold, Anna.

J Mol Med (Berl); 97(8): 1155-1167, 2019 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-31183506

19.

Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis.

Tsoi, Lam C; Rodriguez, Elke; Degenhardt, Frauke; Baurecht, Hansjörg; Wehkamp, Ulrike; Volks, Natalie; Szymczak, Silke; Swindell, William R; Sarkar, Mrinal K; Raja, Kalpana; Shao, Shuai; Patrick, Matthew; Gao, Yilin; Uppala, Ranjitha; Perez White, Bethany E; Getsios, Spiro; Harms, Paul W; Maverakis, Emanual; Elder, James T; Franke, Andre; Gudjonsson, Johann E; Weidinger, Stephan.

J Invest Dermatol; 139(7): 1480-1489, 2019 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-30641038

20.

Identification of genes relevant to symbiosis and competitiveness in Sinorhizobium meliloti using signature-tagged mutants.

Pobigaylo, Nataliya; Szymczak, Silke; Nattkemper, Tim W; Becker, Anke.

Mol Plant Microbe Interact; 21(2): 219-31, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18184066

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