Pesquisa | Biblioteca Virtual em Saúde

1.

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.

Rausch, Tobias; Jones, David T W; Zapatka, Marc; Stütz, Adrian M; Zichner, Thomas; Weischenfeldt, Joachim; Jäger, Natalie; Remke, Marc; Shih, David; Northcott, Paul A; Pfaff, Elke; Tica, Jelena; Wang, Qi; Massimi, Luca; Witt, Hendrik; Bender, Sebastian; Pleier, Sabrina; Cin, Huriye; Hawkins, Cynthia; Beck, Christian; von Deimling, Andreas; Hans, Volkmar; Brors, Benedikt; Eils, Roland; Scheurlen, Wolfram; Blake, Jonathon; Benes, Vladimir; Kulozik, Andreas E; Witt, Olaf; Martin, Dianna; Zhang, Cindy; Porat, Rinnat; Merino, Diana M; Wasserman, Jonathan; Jabado, Nada; Fontebasso, Adam; Bullinger, Lars; Rücker, Frank G; Döhner, Konstanze; Döhner, Hartmut; Koster, Jan; Molenaar, Jan J; Versteeg, Rogier; Kool, Marcel; Tabori, Uri; Malkin, David; Korshunov, Andrey; Taylor, Michael D; Lichter, Peter; Pfister, Stefan M.

Cell; 148(1-2): 59-71, 2012 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-22265402

2.

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.

Dolman, M Emmy M; Poon, Evon; Ebus, Marli E; den Hartog, Ilona J M; van Noesel, Carel J M; Jamin, Yann; Hallsworth, Albert; Robinson, Simon P; Petrie, Kevin; Sparidans, Rolf W; Kok, Robbert J; Versteeg, Rogier; Caron, Huib N; Chesler, Louis; Molenaar, Jan J.

Clin Cancer Res; 21(22): 5100-9, 2015 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-26202950

3.

The landscape of genomic alterations across childhood cancers.

Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A; Johann, Pascal D; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J; Vassal, Gilles; Witt, Hendrik; Burkhardt, Birgit; Kratz, Christian P.

Nature; 555(7696): 321-327, 2018 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-29489754

4.

Author Correction: The landscape of genomic alterations across childhood cancers.

Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A; Johann, Pascal D; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J; Vassal, Gilles; Witt, Hendrik; Burkhardt, Birgit; Kratz, Christian P.

Nature; 559(7714): E10, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29875405

5.

Neuroblastoma stage 4S: Tumor regression rate and risk factors of progressive disease.

Tas, Michelle L; Nagtegaal, Michelle; Kraal, Kathelijne C J M; Tytgat, Godelieve A M; Abeling, Nico G G M; Pluijm, Saskia M F; Zwaan, C Michel; de Keizer, Bart; Molenaar, Jan J; van Noesel, Max M.

Pediatr Blood Cancer; : e28061, 2019 Nov 17.

Artigo em Inglês | MEDLINE | ID: mdl-31736229

6.

Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome.

Foulkes, William D; Kamihara, Junne; Evans, D Gareth R; Brugières, Laurence; Bourdeaut, Franck; Molenaar, Jan J; Walsh, Michael F; Brodeur, Garrett M; Diller, Lisa.

Clin Cancer Res; 23(12): e62-e67, 2017 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-28620006

7.

Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders.

Walsh, Michael F; Chang, Vivian Y; Kohlmann, Wendy K; Scott, Hamish S; Cunniff, Christopher; Bourdeaut, Franck; Molenaar, Jan J; Porter, Christopher C; Sandlund, John T; Plon, Sharon E; Wang, Lisa L; Savage, Sharon A.

Clin Cancer Res; 23(11): e23-e31, 2017 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-28572264

8.

p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy.

Moreno-Smith, Myrthala; Lakoma, Anna; Chen, Zaowen; Tao, Ling; Scorsone, Kathleen A; Schild, Linda; Aviles-Padilla, Kevin; Nikzad, Rana; Zhang, Yankai; Chakraborty, Rikhia; Molenaar, Jan J; Vasudevan, Sanjeev A; Sheehan, Vivien; Kim, Eugene S; Paust, Silke; Shohet, Jason M; Barbieri, Eveline.

Clin Cancer Res; 23(21): 6629-6639, 2017 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-28821555

9.

Retinoblastoma and Neuroblastoma Predisposition and Surveillance.

Kamihara, Junne; Bourdeaut, Franck; Foulkes, William D; Molenaar, Jan J; Mossé, Yaël P; Nakagawara, Akira; Parareda, Andreu; Scollon, Sarah R; Schneider, Kami Wolfe; Skalet, Alison H; States, Lisa J; Walsh, Michael F; Diller, Lisa R; Brodeur, Garrett M.

Clin Cancer Res; 23(13): e98-e106, 2017 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-28674118

10.

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.

Molenaar, Jan J; Koster, Jan; Zwijnenburg, Danny A; van Sluis, Peter; Valentijn, Linda J; van der Ploeg, Ida; Hamdi, Mohamed; van Nes, Johan; Westerman, Bart A; van Arkel, Jennemiek; Ebus, Marli E; Haneveld, Franciska; Lakeman, Arjan; Schild, Linda; Molenaar, Piet; Stroeken, Peter; van Noesel, Max M; Ora, Ingrid; Santo, Evan E; Caron, Huib N; Westerhout, Ellen M; Versteeg, Rogier.

Nature; 483(7391): 589-93, 2012 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-22367537

11.

From class waivers to precision medicine in paediatric oncology.

Pearson, Andrew D J; Pfister, Stefan M; Baruchel, Andre; Bourquin, Jean-Pierre; Casanova, Michela; Chesler, Louis; Doz, François; Eggert, Angelika; Geoerger, Birgit; Jones, David T W; Kearns, Pamela R; Molenaar, Jan J; Morland, Bruce; Schleiermacher, Gudrun; Schulte, Johannes H; Vormoor, Josef; Marshall, Lynley V; Zwaan, C Michel; Vassal, Gilles.

Lancet Oncol; 18(7): e394-e404, 2017 07.

Artigo em Inglês | MEDLINE | ID: mdl-28677575

12.

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin.

Althoff, Kristina; Lindner, Sven; Odersky, Andrea; Mestdagh, Pieter; Beckers, Anneleen; Karczewski, Sarah; Molenaar, Jan J; Bohrer, Anna; Knauer, Shirley; Speleman, Frank; Epple, Matthias; Kozlova, Diana; Yoon, Sena; Baek, Kwanghee; Vandesompele, Jo; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes H.

Int J Cancer; 136(6): 1308-20, 2015 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-25046253

13.

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.

Valentijn, Linda J; Koster, Jan; Haneveld, Franciska; Aissa, Rachida Ait; van Sluis, Peter; Broekmans, Marloes E C; Molenaar, Jan J; van Nes, Johan; Versteeg, Rogier.

Proc Natl Acad Sci U S A; 109(47): 19190-5, 2012 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-23091029

14.

Prevalence and clinical implications of chromothripsis in cancer genomes.

Kloosterman, Wigard P; Koster, Jan; Molenaar, Jan J.

Curr Opin Oncol; 26(1): 64-72, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24305569

15.

Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis.

Molenaar, Jan J; Koster, Jan; Ebus, Marli E; van Sluis, Peter; Westerhout, Ellen M; de Preter, Katleen; Gisselsson, David; Øra, Ingrid; Speleman, Frank; Caron, Huib N; Versteeg, Rogier.

Genes Chromosomes Cancer; 51(1): 10-9, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22034077

16.

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.

Lamers, Fieke; Schild, Linda; Koster, Jan; Speleman, Frank; Øra, Ingrid; Westerhout, Ellen M; van Sluis, Peter; Versteeg, Rogier; Caron, Huib N; Molenaar, Jan J.

BMC Cancer; 12: 285, 2012 Jul 12.

Artigo em Inglês | MEDLINE | ID: mdl-22788920

17.

miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples.

De Preter, Katleen; Mestdagh, Pieter; Vermeulen, Joëlle; Zeka, Fjoralba; Naranjo, Arlene; Bray, Isabella; Castel, Victoria; Chen, Caifu; Drozynska, Elzbieta; Eggert, Angelika; Hogarty, Michael D; Izycka-Swieszewska, Ewa; London, Wendy B; Noguera, Rosa; Piqueras, Marta; Bryan, Kenneth; Schowe, Benjamin; van Sluis, Peter; Molenaar, Jan J; Schramm, Alexander; Schulte, Johannes H; Stallings, Raymond L; Versteeg, Rogier; Laureys, Geneviève; Van Roy, Nadine; Speleman, Frank; Vandesompele, Jo.

Clin Cancer Res; 17(24): 7684-92, 2011 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-22031095

18.

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.

Molenaar, Jan J; Ebus, Marli E; Geerts, Dirk; Koster, Jan; Lamers, Fieke; Valentijn, Linda J; Westerhout, Ellen M; Versteeg, Rogier; Caron, Huib N.

Proc Natl Acad Sci U S A; 106(31): 12968-73, 2009 Aug 04.

Artigo em Inglês | MEDLINE | ID: mdl-19525400

19.

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients.

Fardin, Paolo; Barla, Annalisa; Mosci, Sofia; Rosasco, Lorenzo; Verri, Alessandro; Versteeg, Rogier; Caron, Huib N; Molenaar, Jan J; Ora, Ingrid; Eva, Alessandra; Puppo, Maura; Varesio, Luigi.

Mol Cancer; 9: 185, 2010 Jul 12.

Artigo em Inglês | MEDLINE | ID: mdl-20624283

20.

Towards personalized therapy in pediatric acute lymphoblastic leukemia: RAS mutations and prednisolone resistance.

Ariës, Ingrid M; van den Dungen, Rosanna E; Koudijs, Marco J; Cuppen, Edwin; Voest, Emile; Molenaar, Jan J; Caron, Huib N; Pieters, Rob; den Boer, Monique L.

Haematologica; 100(4): e132-6, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25480501

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