Pesquisa | Biblioteca Virtual em Saúde

1.

Structure of the Respiratory Syncytial Virus Polymerase Complex.

Gilman, Morgan S A; Liu, Cheng; Fung, Amy; Behera, Ishani; Jordan, Paul; Rigaux, Peter; Ysebaert, Nina; Tcherniuk, Sergey; Sourimant, Julien; Eléouët, Jean-François; Sutto-Ortiz, Priscila; Decroly, Etienne; Roymans, Dirk; Jin, Zhinan; McLellan, Jason S.

Cell; 179(1): 193-204.e14, 2019 Sep 19.

Artigo em Inglês | MEDLINE | ID: mdl-31495574

2.

Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.

Goodwin, Eileen; Gilman, Morgan S A; Wrapp, Daniel; Chen, Man; Ngwuta, Joan O; Moin, Syed M; Bai, Patricia; Sivasubramanian, Arvind; Connor, Ruth I; Wright, Peter F; Graham, Barney S; McLellan, Jason S; Walker, Laura M.

Immunity; 48(2): 339-349.e5, 2018 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-29396163

3.

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Liao, Hua-Xin; Bonsignori, Mattia; Alam, S Munir; McLellan, Jason S; Tomaras, Georgia D; Moody, M Anthony; Kozink, Daniel M; Hwang, Kwan-Ki; Chen, Xi; Tsao, Chun-Yen; Liu, Pinghuang; Lu, Xiaozhi; Parks, Robert J; Montefiori, David C; Ferrari, Guido; Pollara, Justin; Rao, Mangala; Peachman, Kristina K; Santra, Sampa; Letvin, Norman L; Karasavvas, Nicos; Yang, Zhi-Yong; Dai, Kaifan; Pancera, Marie; Gorman, Jason; Wiehe, Kevin; Nicely, Nathan I; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Tartaglia, James; Sinangil, Faruk; Kim, Jerome H; Michael, Nelson L; Kepler, Thomas B; Kwong, Peter D; Mascola, John R; Nabel, Gary J; Pinter, Abraham; Zolla-Pazner, Susan; Haynes, Barton F.

Immunity; 38(1): 176-86, 2013 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-23313589

4.

Pre-fusion structure of a human coronavirus spike protein.

Kirchdoerfer, Robert N; Cottrell, Christopher A; Wang, Nianshuang; Pallesen, Jesper; Yassine, Hadi M; Turner, Hannah L; Corbett, Kizzmekia S; Graham, Barney S; McLellan, Jason S; Ward, Andrew B.

Nature; 531(7592): 118-21, 2016 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-26935699

5.

Structure-Based Vaccine Antigen Design.

Graham, Barney S; Gilman, Morgan S A; McLellan, Jason S.

Annu Rev Med; 70: 91-104, 2019 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-30691364

6.

Alternative conformations of a major antigenic site on RSV F.

Jones, Harrison G; Battles, Michael B; Lin, Chun-Chi; Bianchi, Siro; Corti, Davide; McLellan, Jason S.

PLoS Pathog; 15(7): e1007944, 2019 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-31306469

7.

The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation.

Wrapp, Daniel; McLellan, Jason S.

J Virol; 93(23)2019 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-31534041

8.

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.

Jones, Harrison G; Ritschel, Tina; Pascual, Gabriel; Brakenhoff, Just P J; Keogh, Elissa; Furmanova-Hollenstein, Polina; Lanckacker, Ellen; Wadia, Jehangir S; Gilman, Morgan S A; Williamson, R Anthony; Roymans, Dirk; van 't Wout, Angélique B; Langedijk, Johannes P; McLellan, Jason S.

PLoS Pathog; 14(3): e1006935, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29509814

9.

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

Pallesen, Jesper; Wang, Nianshuang; Corbett, Kizzmekia S; Wrapp, Daniel; Kirchdoerfer, Robert N; Turner, Hannah L; Cottrell, Christopher A; Becker, Michelle M; Wang, Lingshu; Shi, Wei; Kong, Wing-Pui; Andres, Erica L; Kettenbach, Arminja N; Denison, Mark R; Chappell, James D; Graham, Barney S; Ward, Andrew B; McLellan, Jason S.

Proc Natl Acad Sci U S A; 114(35): E7348-E7357, 2017 08 29.

Artigo em Inglês | MEDLINE | ID: mdl-28807998

10.

Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F₂ Subunit Are Critical for Its Fusion Activity.

Hicks, Stephanie N; Chaiwatpongsakorn, Supranee; Costello, Heather M; McLellan, Jason S; Ray, William; Peeples, Mark E.

J Virol; 92(15)2018 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-29743373

11.

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape.

Wang, Lingshu; Shi, Wei; Chappell, James D; Joyce, M Gordon; Zhang, Yi; Kanekiyo, Masaru; Becker, Michelle M; van Doremalen, Neeltje; Fischer, Robert; Wang, Nianshuang; Corbett, Kizzmekia S; Choe, Misook; Mason, Rosemarie D; Van Galen, Joseph G; Zhou, Tongqing; Saunders, Kevin O; Tatti, Kathleen M; Haynes, Lia M; Kwong, Peter D; Modjarrad, Kayvon; Kong, Wing-Pui; McLellan, Jason S; Denison, Mark R; Munster, Vincent J; Mascola, John R; Graham, Barney S.

J Virol; 2018 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-29514901

12.

Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab.

Zhao, Min; Zheng, Zi-Zheng; Chen, Man; Modjarrad, Kayvon; Zhang, Wei; Zhan, Lu-Ting; Cao, Jian-Li; Sun, Yong-Peng; McLellan, Jason S; Graham, Barney S; Xia, Ning-Shao.

J Virol; 91(15)2017 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-28539438

13.

Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.

Liang, Bo; Ngwuta, Joan O; Surman, Sonja; Kabatova, Barbora; Liu, Xiang; Lingemann, Matthias; Liu, Xueqiao; Yang, Lijuan; Herbert, Richard; Swerczek, Joanna; Chen, Man; Moin, Syed M; Kumar, Azad; McLellan, Jason S; Kwong, Peter D; Graham, Barney S; Collins, Peter L; Munir, Shirin.

J Virol; 91(15)2017 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-28539444

14.

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex.

Ha, Sha; Li, Fengsheng; Troutman, Matthew C; Freed, Daniel C; Tang, Aimin; Loughney, John W; Wang, Dai; Wang, I-Ming; Vlasak, Josef; Nickle, David C; Rustandi, Richard R; Hamm, Melissa; DePhillips, Pete A; Zhang, Ningyan; McLellan, Jason S; Zhu, Hua; Adler, Stuart P; McVoy, Michael A; An, Zhiqiang; Fu, Tong-Ming.

J Virol; 91(7)2017 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-28077654

15.

Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation.

Más, Vicente; Rodriguez, Laura; Olmedillas, Eduardo; Cano, Olga; Palomo, Concepción; Terrón, María C; Luque, Daniel; Melero, José A; McLellan, Jason S.

PLoS Pathog; 12(9): e1005859, 2016 09.

Artigo em Inglês | MEDLINE | ID: mdl-27611367

16.

Molecular mechanism of respiratory syncytial virus fusion inhibitors.

Battles, Michael B; Langedijk, Johannes P; Furmanova-Hollenstein, Polina; Chaiwatpongsakorn, Supranee; Costello, Heather M; Kwanten, Leen; Vranckx, Luc; Vink, Paul; Jaensch, Steffen; Jonckers, Tim H M; Koul, Anil; Arnoult, Eric; Peeples, Mark E; Roymans, Dirk; McLellan, Jason S.

Nat Chem Biol; 12(2): 87-93, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26641933

17.

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2.

Rolland, Morgane; Edlefsen, Paul T; Larsen, Brendan B; Tovanabutra, Sodsai; Sanders-Buell, Eric; Hertz, Tomer; deCamp, Allan C; Carrico, Chris; Menis, Sergey; Magaret, Craig A; Ahmed, Hasan; Juraska, Michal; Chen, Lennie; Konopa, Philip; Nariya, Snehal; Stoddard, Julia N; Wong, Kim; Zhao, Hong; Deng, Wenjie; Maust, Brandon S; Bose, Meera; Howell, Shana; Bates, Adam; Lazzaro, Michelle; O'Sullivan, Annemarie; Lei, Esther; Bradfield, Andrea; Ibitamuno, Grace; Assawadarachai, Vatcharain; O'Connell, Robert J; deSouza, Mark S; Nitayaphan, Sorachai; Rerks-Ngarm, Supachai; Robb, Merlin L; McLellan, Jason S; Georgiev, Ivelin; Kwong, Peter D; Carlson, Jonathan M; Michael, Nelson L; Schief, William R; Gilbert, Peter B; Mullins, James I; Kim, Jerome H.

Nature; 490(7420): 417-20, 2012 Oct 18.

Artigo em Inglês | MEDLINE | ID: mdl-22960785

18.

Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.

Liang, Bo; Ngwuta, Joan O; Herbert, Richard; Swerczek, Joanna; Dorward, David W; Amaro-Carambot, Emerito; Mackow, Natalie; Kabatova, Barbora; Lingemann, Matthias; Surman, Sonja; Yang, Lijuan; Chen, Man; Moin, Syed M; Kumar, Azad; McLellan, Jason S; Kwong, Peter D; Graham, Barney S; Schaap-Nutt, Anne; Collins, Peter L; Munir, Shirin.

J Virol; 90(21): 10022-10038, 2016 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-27581977

19.

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.

Gilman, Morgan S A; Moin, Syed M; Mas, Vicente; Chen, Man; Patel, Nita K; Kramer, Kari; Zhu, Qing; Kabeche, Stephanie C; Kumar, Azad; Palomo, Concepción; Beaumont, Tim; Baxa, Ulrich; Ulbrandt, Nancy D; Melero, José A; Graham, Barney S; McLellan, Jason S.

PLoS Pathog; 11(7): e1005035, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-26161532

20.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.

McLellan, Jason S; Pancera, Marie; Carrico, Chris; Gorman, Jason; Julien, Jean-Philippe; Khayat, Reza; Louder, Robert; Pejchal, Robert; Sastry, Mallika; Dai, Kaifan; O'Dell, Sijy; Patel, Nikita; Shahzad-ul-Hussan, Syed; Yang, Yongping; Zhang, Baoshan; Zhou, Tongqing; Zhu, Jiang; Boyington, Jeffrey C; Chuang, Gwo-Yu; Diwanji, Devan; Georgiev, Ivelin; Kwon, Young Do; Lee, Doyung; Louder, Mark K; Moquin, Stephanie; Schmidt, Stephen D; Yang, Zhi-Yong; Bonsignori, Mattia; Crump, John A; Kapiga, Saidi H; Sam, Noel E; Haynes, Barton F; Burton, Dennis R; Koff, Wayne C; Walker, Laura M; Phogat, Sanjay; Wyatt, Richard; Orwenyo, Jared; Wang, Lai-Xi; Arthos, James; Bewley, Carole A; Mascola, John R; Nabel, Gary J; Schief, William R; Ward, Andrew B; Wilson, Ian A; Kwong, Peter D.

Nature; 480(7377): 336-43, 2011 Nov 23.

Artigo em Inglês | MEDLINE | ID: mdl-22113616

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