Pesquisa | Biblioteca Virtual em Saúde

1.

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle.

Taylor, D Leland; Jackson, Anne U; Narisu, Narisu; Hemani, Gibran; Erdos, Michael R; Chines, Peter S; Swift, Amy; Idol, Jackie; Didion, John P; Welch, Ryan P; Kinnunen, Leena; Saramies, Jouko; Lakka, Timo A; Laakso, Markku; Tuomilehto, Jaakko; Parker, Stephen C J; Koistinen, Heikki A; Davey Smith, George; Boehnke, Michael; Scott, Laura J; Birney, Ewan; Collins, Francis S.

Proc Natl Acad Sci U S A; 116(22): 10883-10888, 2019 May 28.

Artigo em Inglês | MEDLINE | ID: mdl-31076557

2.

Age-related clonal hematopoiesis associated with adverse outcomes.

Jaiswal, Siddhartha; Fontanillas, Pierre; Flannick, Jason; Manning, Alisa; Grauman, Peter V; Mar, Brenton G; Lindsley, R Coleman; Mermel, Craig H; Burtt, Noel; Chavez, Alejandro; Higgins, John M; Moltchanov, Vladislav; Kuo, Frank C; Kluk, Michael J; Henderson, Brian; Kinnunen, Leena; Koistinen, Heikki A; Ladenvall, Claes; Getz, Gad; Correa, Adolfo; Banahan, Benjamin F; Gabriel, Stacey; Kathiresan, Sekar; Stringham, Heather M; McCarthy, Mark I; Boehnke, Michael; Tuomilehto, Jaakko; Haiman, Christopher; Groop, Leif; Atzmon, Gil; Wilson, James G; Neuberg, Donna; Altshuler, David; Ebert, Benjamin L.

N Engl J Med; 371(26): 2488-98, 2014 Dec 25.

Artigo em Inglês | MEDLINE | ID: mdl-25426837

3.

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.

Wu, Ying; Waite, Lindsay L; Jackson, Anne U; Sheu, Wayne H-H; Buyske, Steven; Absher, Devin; Arnett, Donna K; Boerwinkle, Eric; Bonnycastle, Lori L; Carty, Cara L; Cheng, Iona; Cochran, Barbara; Croteau-Chonka, Damien C; Dumitrescu, Logan; Eaton, Charles B; Franceschini, Nora; Guo, Xiuqing; Henderson, Brian E; Hindorff, Lucia A; Kim, Eric; Kinnunen, Leena; Komulainen, Pirjo; Lee, Wen-Jane; Le Marchand, Loic; Lin, Yi; Lindström, Jaana; Lingaas-Holmen, Oddgeir; Mitchell, Sabrina L; Narisu, Narisu; Robinson, Jennifer G; Schumacher, Fred; Stancáková, Alena; Sundvall, Jouko; Sung, Yun-Ju; Swift, Amy J; Wang, Wen-Chang; Wilkens, Lynne; Wilsgaard, Tom; Young, Alicia M; Adair, Linda S; Ballantyne, Christie M; Buzková, Petra; Chakravarti, Aravinda; Collins, Francis S; Duggan, David; Feranil, Alan B; Ho, Low-Tone; Hung, Yi-Jen; Hunt, Steven C; Hveem, Kristian.

PLoS Genet; 9(3): e1003379, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23555291

4.

Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring.

Miettinen, Maija E; Smart, Melissa C; Kinnunen, Leena; Mathews, Christopher; Harjutsalo, Valma; Surcel, Heljä-Marja; Lamberg-Allardt, Christel; Tuomilehto, Jaakko; Hitman, Graham A.

Diabetologia; 58(10): 2278-83, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26109216

5.

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Morris, Andrew P; Voight, Benjamin F; Teslovich, Tanya M; Ferreira, Teresa; Segrè, Ayellet V; Steinthorsdottir, Valgerdur; Strawbridge, Rona J; Khan, Hassan; Grallert, Harald; Mahajan, Anubha; Prokopenko, Inga; Kang, Hyun Min; Dina, Christian; Esko, Tonu; Fraser, Ross M; Kanoni, Stavroula; Kumar, Ashish; Lagou, Vasiliki; Langenberg, Claudia; Luan, Jian'an; Lindgren, Cecilia M; Müller-Nurasyid, Martina; Pechlivanis, Sonali; Rayner, N William; Scott, Laura J; Wiltshire, Steven; Yengo, Loic; Kinnunen, Leena; Rossin, Elizabeth J; Raychaudhuri, Soumya; Johnson, Andrew D; Dimas, Antigone S; Loos, Ruth J F; Vedantam, Sailaja; Chen, Han; Florez, Jose C; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Couper, David J; Kao, Wen Hong L; Li, Man; Cornelis, Marilyn C; Kraft, Peter; Sun, Qi; van Dam, Rob M; Stringham, Heather M; Chines, Peter S; Fischer, Krista; Fontanillas, Pierre.

Nat Genet; 44(9): 981-90, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22885922

6.

Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.

Klinker, Matthew W; Schiller, Jennifer J; Magnuson, Victoria L; Wang, Tao; Basken, Joel; Veth, Kerry; Pearce, Kaela I; Kinnunen, Leena; Harjutsalo, Valma; Wang, Xujing; Tuomilehto, Jaakko; Sarti, Cinzia; Ghosh, Soumitra.

Immunogenetics; 62(2): 101-7, 2010 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-20033399

7.

Serum 25-hydroxyvitamin D in juvenile idiopathic arthritis patients in Finland.

Miettinen, Maija E; Kinnunen, Leena; Harjutsalo, Valma; Reinert-Hartwall, Linnea; Lamberg-Allardt, Christel; Tuomilehto, Jaakko; Säilä, Hanna.

Clin Exp Rheumatol; 31(6): 988, 2013 Nov-Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24321448

8.

The effect of age and gender on the genetic regulation of serum 25-hydroxyvitamin D - the FIN-D2D population-based study.

Miettinen, Maija E; Smart, Melissa C; Kinnunen, Leena; Keinänen-Kiukaanniemi, Sirkka; Moilanen, Leena; Puolijoki, Hannu; Saltevo, Juha; Oksa, Heikki; Hitman, Graham A; Tuomilehto, Jaakko; Peltonen, Markku.

J Steroid Biochem Mol Biol; 178: 229-233, 2018 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-29287921

9.

Interactions between genetic variation and cellular environment in skeletal muscle gene expression.

Taylor, D Leland; Knowles, David A; Scott, Laura J; Ramirez, Andrea H; Casale, Francesco Paolo; Wolford, Brooke N; Guan, Li; Varshney, Arushi; Albanus, Ricardo D'Oliveira; Parker, Stephen C J; Narisu, Narisu; Chines, Peter S; Erdos, Michael R; Welch, Ryan P; Kinnunen, Leena; Saramies, Jouko; Sundvall, Jouko; Lakka, Timo A; Laakso, Markku; Tuomilehto, Jaakko; Koistinen, Heikki A; Stegle, Oliver; Boehnke, Michael; Birney, Ewan; Collins, Francis S.

PLoS One; 13(4): e0195788, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-29659628

10.

How well does the metabolic syndrome defined by five definitions predict incident diabetes and incident coronary heart disease in a Chinese population?

Wang, Jian-jun; Li, Hong-bing; Kinnunen, Leena; Hu, Gang; Järvinen, Tiina M; Miettinen, Maija E; Yuan, Shenyuan; Tuomilehto, Jaakko.

Atherosclerosis; 192(1): 161-8, 2007 May.

Artigo em Inglês | MEDLINE | ID: mdl-16720024

11.

A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland.

Qiao, Qing; Osterholm, Anne-May; He, Bing; Pitkäniemi, Janne; Cordell, Heather J; Sarti, Cinzia; Kinnunen, Leena; Tuomilehto-Wolf, Eva; Tryggvason, Karl; Tuomilehto, Jaakko.

BMC Genet; 8: 84, 2007 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-18093291

12.

Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child.

Miettinen, Maija E; Smart, Melissa C; Kinnunen, Leena; Harjutsalo, Valma; Reinert-Hartwall, Linnea; Ylivinkka, Irene; Surcel, Heljä-Marja; Lamberg-Allardt, Christel; Hitman, Graham A; Tuomilehto, Jaakko.

PLoS One; 12(10): e0184942, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28976992

13.

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

Justice, Anne E; Winkler, Thomas W; Feitosa, Mary F; Graff, Misa; Fisher, Virginia A; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S; Ahluwalia, Tarunveer S; Chu, Audrey Y; Heard-Costa, Nancy L; Lim, Elise; Perez, Jeremiah; Eicher, John D; Kutalik, Zoltán; Xue, Luting; Mahajan, Anubha; Renström, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F; Bonnefond, Amelie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Neergaard Harder, Marie; Horikoshi, Momoko; Huang, Tao; Huffman, Jennifer E; Jackson, Anne U; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an.

Nat Commun; 8: 14977, 2017 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-28443625

14.

The genetic regulatory signature of type 2 diabetes in human skeletal muscle.

Scott, Laura J; Erdos, Michael R; Huyghe, Jeroen R; Welch, Ryan P; Beck, Andrew T; Wolford, Brooke N; Chines, Peter S; Didion, John P; Narisu, Narisu; Stringham, Heather M; Taylor, D Leland; Jackson, Anne U; Vadlamudi, Swarooparani; Bonnycastle, Lori L; Kinnunen, Leena; Saramies, Jouko; Sundvall, Jouko; Albanus, Ricardo D'Oliveira; Kiseleva, Anna; Hensley, John; Crawford, Gregory E; Jiang, Hui; Wen, Xiaoquan; Watanabe, Richard M; Lakka, Timo A; Mohlke, Karen L; Laakso, Markku; Tuomilehto, Jaakko; Koistinen, Heikki A; Boehnke, Michael; Collins, Francis S; Parker, Stephen C J.

Nat Commun; 7: 11764, 2016 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-27353450

15.

Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study.

Hyttinen, Valma; Kaprio, Jaakko; Kinnunen, Leena; Koskenvuo, Markku; Tuomilehto, Jaakko.

Diabetes; 52(4): 1052-5, 2003 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-12663480

16.

Association of serum 25-hydroxyvitamin D with lifestyle factors and metabolic and cardiovascular disease markers: population-based cross-sectional study (FIN-D2D).

Miettinen, Maija E; Kinnunen, Leena; Leiviskä, Jaana; Keinänen-Kiukaanniemi, Sirkka; Korpi-Hyövälti, Eeva; Niskanen, Leo; Oksa, Heikki; Saaristo, Timo; Tuomilehto, Jaakko; Vanhala, Mauno; Uusitupa, Matti; Peltonen, Markku.

PLoS One; 9(7): e100235, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25000408

17.

Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.

Melén, Krister; Kinnunen, Leena; Fagerlund, Riku; Ikonen, Niina; Twu, Karen Y; Krug, Robert M; Julkunen, Ilkka.

J Virol; 81(11): 5995-6006, 2007 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-17376915

18.

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

Scott, Laura J; Mohlke, Karen L; Bonnycastle, Lori L; Willer, Cristen J; Li, Yun; Duren, William L; Erdos, Michael R; Stringham, Heather M; Chines, Peter S; Jackson, Anne U; Prokunina-Olsson, Ludmila; Ding, Chia-Jen; Swift, Amy J; Narisu, Narisu; Hu, Tianle; Pruim, Randall; Xiao, Rui; Li, Xiao-Yi; Conneely, Karen N; Riebow, Nancy L; Sprau, Andrew G; Tong, Maurine; White, Peggy P; Hetrick, Kurt N; Barnhart, Michael W; Bark, Craig W; Goldstein, Janet L; Watkins, Lee; Xiang, Fang; Saramies, Jouko; Buchanan, Thomas A; Watanabe, Richard M; Valle, Timo T; Kinnunen, Leena; Abecasis, Gonçalo R; Pugh, Elizabeth W; Doheny, Kimberly F; Bergman, Richard N; Tuomilehto, Jaakko; Collins, Francis S; Boehnke, Michael.

Science; 316(5829): 1341-5, 2007 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-17463248

19.

Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database.

Willer, Cristen J; Scott, Laura J; Bonnycastle, Lori L; Jackson, Anne U; Chines, Peter; Pruim, Randall; Bark, Craig W; Tsai, Ya-Yu; Pugh, Elizabeth W; Doheny, Kimberly F; Kinnunen, Leena; Mohlke, Karen L; Valle, Timo T; Bergman, Richard N; Tuomilehto, Jaakko; Collins, Francis S; Boehnke, Michael.

Genet Epidemiol; 30(2): 180-90, 2006 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-16374835

20.

NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4.

Fagerlund, Riku; Kinnunen, Leena; Köhler, Matthias; Julkunen, Ilkka; Melén, Krister.

J Biol Chem; 280(16): 15942-51, 2005 Apr 22.

Artigo em Inglês | MEDLINE | ID: mdl-15677444

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