Pesquisa | Biblioteca Virtual em Saúde

1.

Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics.

LeDuc, Richard D; Fellers, Ryan T; Early, Bryan P; Greer, Joseph B; Shams, Daniel P; Thomas, Paul M; Kelleher, Neil L.

Mol Cell Proteomics; 18(4): 796-805, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30647073

2.

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

Ntai, Ioanna; Fornelli, Luca; DeHart, Caroline J; Hutton, Josiah E; Doubleday, Peter F; LeDuc, Richard D; van Nispen, Alexandra J; Fellers, Ryan T; Whiteley, Gordon; Boja, Emily S; Rodriguez, Henry; Kelleher, Neil L.

Proc Natl Acad Sci U S A; 115(16): 4140-4145, 2018 04 17.

Artigo em Inglês | MEDLINE | ID: mdl-29610327

3.

Identification and Quantification of Proteoforms by Mass Spectrometry.

Schaffer, Leah V; Millikin, Robert J; Miller, Rachel M; Anderson, Lissa C; Fellers, Ryan T; Ge, Ying; Kelleher, Neil L; LeDuc, Richard D; Liu, Xiaowen; Payne, Samuel H; Sun, Liangliang; Thomas, Paul M; Tucholski, Trisha; Wang, Zhe; Wu, Si; Wu, Zhijie; Yu, Dahang; Shortreed, Michael R; Smith, Lloyd M.

Proteomics; 19(10): e1800361, 2019 May.

Artigo em Inglês | MEDLINE | ID: mdl-31050378

4.

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol.

Park, Hae-Min; Satta, Rosalba; Davis, Roderick G; Goo, Young Ah; LeDuc, Richard D; Fellers, Ryan T; Greer, Joseph B; Romanova, Elena V; Rubakhin, Stanislav S; Tai, Rex; Thomas, Paul M; Sweedler, Jonathan V; Kelleher, Neil L; Patrie, Steven M; Lasek, Amy W.

J Proteome Res; 18(11): 3999-4012, 2019 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-31550894

5.

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms.

Huguet, Romain; Mullen, Christopher; Srzentic, Kristina; Greer, Joseph B; Fellers, Ryan T; Zabrouskov, Vlad; Syka, John E P; Kelleher, Neil L; Fornelli, Luca.

Anal Chem; 2019 Nov 22.

Artigo em Inglês | MEDLINE | ID: mdl-31714757

6.

An informatic framework for decoding protein complexes by top-down mass spectrometry.

Skinner, Owen S; Havugimana, Pierre C; Haverland, Nicole A; Fornelli, Luca; Early, Bryan P; Greer, Joseph B; Fellers, Ryan T; Durbin, Kenneth R; Do Vale, Luis H F; Melani, Rafael D; Seckler, Henrique S; Nelp, Micah T; Belov, Mikhail E; Horning, Stevan R; Makarov, Alexander A; LeDuc, Richard D; Bandarian, Vahe; Compton, Philip D; Kelleher, Neil L.

Nat Methods; 13(3): 237-40, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26780093

7.

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques.

Fornelli, Luca; Srzentic, Kristina; Huguet, Romain; Mullen, Christopher; Sharma, Seema; Zabrouskov, Vlad; Fellers, Ryan T; Durbin, Kenneth R; Compton, Philip D; Kelleher, Neil L.

Anal Chem; 90(14): 8421-8429, 2018 Jul 17.

Artigo em Inglês | MEDLINE | ID: mdl-29894161

8.

Capillary HILIC-MS: A New Tool for Sensitive Top-Down Proteomics.

Gargano, Andrea F G; Roca, Liana S; Fellers, Ryan T; Bocxe, Max; Domínguez-Vega, Elena; Somsen, Govert W.

Anal Chem; 90(11): 6601-6609, 2018 Jun 05.

Artigo em Inglês | MEDLINE | ID: mdl-29722972

9.

The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins.

Riley, Nicholas M; Sikora, Jacek W; Seckler, Henrique S; Greer, Joseph B; Fellers, Ryan T; LeDuc, Richard D; Westphall, Michael S; Thomas, Paul M; Kelleher, Neil L; Coon, Joshua J.

Anal Chem; 90(14): 8553-8560, 2018 Jul 17.

Artigo em Inglês | MEDLINE | ID: mdl-29924586

10.

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.

Davis, Roderick G; Park, Hae-Min; Kim, Kyunggon; Greer, Joseph B; Fellers, Ryan T; LeDuc, Richard D; Romanova, Elena V; Rubakhin, Stanislav S; Zombeck, Jonathan A; Wu, Cong; Yau, Peter M; Gao, Peng; van Nispen, Alexandra J; Patrie, Steven M; Thomas, Paul M; Sweedler, Jonathan V; Rhodes, Justin S; Kelleher, Neil L.

Anal Chem; 90(6): 3802-3810, 2018 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-29481055

11.

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Zheng, Yupeng; Fornelli, Luca; Compton, Philip D; Sharma, Seema; Canterbury, Jesse; Mullen, Christopher; Zabrouskov, Vlad; Fellers, Ryan T; Thomas, Paul M; Licht, Jonathan D; Senko, Michael W; Kelleher, Neil L.

Mol Cell Proteomics; 15(3): 776-90, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26272979

12.

Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.

Ntai, Ioanna; LeDuc, Richard D; Fellers, Ryan T; Erdmann-Gilmore, Petra; Davies, Sherri R; Rumsey, Jeanne; Early, Bryan P; Thomas, Paul M; Li, Shunqiang; Compton, Philip D; Ellis, Matthew J C; Ruggles, Kelly V; Fenyö, David; Boja, Emily S; Rodriguez, Henry; Townsend, R Reid; Kelleher, Neil L.

Mol Cell Proteomics; 15(1): 45-56, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26503891

13.

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer.

Cleland, Timothy P; DeHart, Caroline J; Fellers, Ryan T; VanNispen, Alexandra J; Greer, Joseph B; LeDuc, Richard D; Parker, W Ryan; Thomas, Paul M; Kelleher, Neil L; Brodbelt, Jennifer S.

J Proteome Res; 16(5): 2072-2079, 2017 05 05.

Artigo em Inglês | MEDLINE | ID: mdl-28412815

14.

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry.

Anderson, Lissa C; DeHart, Caroline J; Kaiser, Nathan K; Fellers, Ryan T; Smith, Donald F; Greer, Joseph B; LeDuc, Richard D; Blakney, Greg T; Thomas, Paul M; Kelleher, Neil L; Hendrickson, Christopher L.

J Proteome Res; 16(2): 1087-1096, 2017 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-27936753

15.

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer.

Fornelli, Luca; Durbin, Kenneth R; Fellers, Ryan T; Early, Bryan P; Greer, Joseph B; LeDuc, Richard D; Compton, Philip D; Kelleher, Neil L.

J Proteome Res; 16(2): 609-618, 2017 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-28152595

16.

A five-level classification system for proteoform identifications.

Smith, Lloyd M; Thomas, Paul M; Shortreed, Michael R; Schaffer, Leah V; Fellers, Ryan T; LeDuc, Richard D; Tucholski, Trisha; Ge, Ying; Agar, Jeffrey N; Anderson, Lissa C; Chamot-Rooke, Julia; Gault, Joseph; Loo, Joseph A; Pasa-Tolic, Ljiljana; Robinson, Carol V; Schlüter, Hartmut; Tsybin, Yury O; Vilaseca, Marta; Vizcaíno, Juan Antonio; Danis, Paul O; Kelleher, Neil L.

Nat Methods; 16(10): 939-940, 2019 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-31451767

17.

Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection.

Savaryn, John P; Toby, Timothy K; Catherman, Adam D; Fellers, Ryan T; LeDuc, Richard D; Thomas, Paul M; Friedewald, John J; Salomon, Daniel R; Abecassis, Michael M; Kelleher, Neil L.

Proteomics; 16(14): 2048-58, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27120713

18.

Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa.

Durbin, Kenneth R; Fornelli, Luca; Fellers, Ryan T; Doubleday, Peter F; Narita, Masashi; Kelleher, Neil L.

J Proteome Res; 15(3): 976-82, 2016 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-26795204

19.

ProSight Lite: graphical software to analyze top-down mass spectrometry data.

Fellers, Ryan T; Greer, Joseph B; Early, Bryan P; Yu, Xiang; LeDuc, Richard D; Kelleher, Neil L; Thomas, Paul M.

Proteomics; 15(7): 1235-8, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25828799

20.

Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

Catherman, Adam D; Durbin, Kenneth R; Ahlf, Dorothy R; Early, Bryan P; Fellers, Ryan T; Tran, John C; Thomas, Paul M; Kelleher, Neil L.

Mol Cell Proteomics; 12(12): 3465-73, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24023390

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