Pesquisa | Biblioteca Virtual em Saúde

1.

FXR Regulates Intestinal Cancer Stem Cell Proliferation.

Fu, Ting; Coulter, Sally; Yoshihara, Eiji; Oh, Tae Gyu; Fang, Sungsoon; Cayabyab, Fritz; Zhu, Qiyun; Zhang, Tong; Leblanc, Mathias; Liu, Sihao; He, Mingxiao; Waizenegger, Wanda; Gasser, Emanuel; Schnabl, Bernd; Atkins, Annette R; Yu, Ruth T; Knight, Rob; Liddle, Christopher; Downes, Michael; Evans, Ronald M.

Cell; 176(5): 1098-1112.e18, 2019 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-30794774

2.

Vitamin D Switches BAF Complexes to Protect ß Cells.

Wei, Zong; Yoshihara, Eiji; He, Nanhai; Hah, Nasun; Fan, Weiwei; Pinto, Antonio F M; Huddy, Timothy; Wang, Yuhao; Ross, Brittany; Estepa, Gabriela; Dai, Yang; Ding, Ning; Sherman, Mara H; Fang, Sungsoon; Zhao, Xuan; Liddle, Christopher; Atkins, Annette R; Yu, Ruth T; Downes, Michael; Evans, Ronald M.

Cell; 173(5): 1135-1149.e15, 2018 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-29754817

3.

RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis.

Oh, Se Kyu; Kim, Dongha; Kim, Kyeongkyu; Boo, Kyungjin; Yu, Young Suk; Kim, Ik Soo; Jeon, Yoon; Im, Sun-Kyoung; Lee, Su-Hyung; Lee, Ji Min; Ko, Younhee; Lee, Ho; Park, Daechan; Fang, Sungsoon; Baek, Sung Hee.

Proc Natl Acad Sci U S A; 116(42): 21140-21149, 2019 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-31570593

4.

Depletion of fat-resident Treg cells prevents age-associated insulin resistance.

Bapat, Sagar P; Myoung Suh, Jae; Fang, Sungsoon; Liu, Sihao; Zhang, Yang; Cheng, Albert; Zhou, Carmen; Liang, Yuqiong; LeBlanc, Mathias; Liddle, Christopher; Atkins, Annette R; Yu, Ruth T; Downes, Michael; Evans, Ronald M; Zheng, Ye.

Nature; 528(7580): 137-41, 2015 Dec 03.

Artigo em Inglês | MEDLINE | ID: mdl-26580014

5.

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

Hong, Suk-Hyun; Fang, Sungsoon; Lu, Benson C; Nofsinger, Russell; Kawakami, Yasuhiko; Castro, Glenda L; Yin, Yunqiang; Lin, Chengqi; Yu, Ruth T; Downes, Michael; Izpisúa Belmonte, Juan Carlos; Shilatifard, Ali; Evans, Ronald M.

Proc Natl Acad Sci U S A; 115(41): 10381-10386, 2018 10 09.

Artigo em Inglês | MEDLINE | ID: mdl-30254164

6.

Anti-obesity effect of taurine through inhibition of adipogenesis in white fat tissue but not in brown fat tissue in a high-fat diet-induced obese mouse model.

Kim, Kyoung Soo; Jang, Min Ju; Fang, Sungsoon; Yoon, Seul Gi; Kim, Il Yong; Seong, Je Kyung; Yang, Hyung-In; Hahm, Dae Hyun.

Amino Acids; 2018 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-30255260

7.

Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity.

Kim, Young-Chae; Fang, Sungsoon; Byun, Sangwon; Seok, Sunmi; Kemper, Byron; Kemper, Jongsook Kim.

Hepatology; 62(1): 220-31, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-25545350

8.

Microbiology: Wealth management in the gut.

Fang, Sungsoon; Evans, Ronald M.

Nature; 500(7464): 538-9, 2013 Aug 29.

Artigo em Inglês | MEDLINE | ID: mdl-23985869

9.

Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance.

Fang, Sungsoon; Suh, Jae Myoung; Atkins, Annette R; Hong, Suk-Hyun; Leblanc, Mathias; Nofsinger, Russell R; Yu, Ruth T; Downes, Michael; Evans, Ronald M.

Proc Natl Acad Sci U S A; 108(8): 3412-7, 2011 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-21300871

10.

Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.

Fang, Sungsoon; Miao, Ji; Xiang, Lingjin; Ponugoti, Bhaskar; Treuter, Eckardt; Kemper, Jongsook Kim.

Mol Cell Biol; 27(4): 1407-24, 2007 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-17145766

11.

Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes.

Kim, Jiwoon; Ahn, Chul Woo; Fang, Sungsoon; Lee, Hye Sun; Park, Jong Suk.

Medicine (Baltimore); 98(46): e17918, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31725641

12.

Combination treatment with n-3 polyunsaturated fatty acids and ursodeoxycholic acid dissolves cholesterol gallstones in mice.

Jang, Sung Ill; Fang, Sungsoon; Kim, Kwang Pyo; Ko, Younhee; Kim, Hyoseon; Oh, Jieun; Hong, Ga Young; Lee, Su Yeon; Kim, Joon Mee; Noh, Ilkoo; Lee, Dong Ki.

Sci Rep; 9(1): 12740, 2019 Sep 04.

Artigo em Inglês | MEDLINE | ID: mdl-31484954

13.

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.

Ponugoti, Bhaskar; Fang, Sungsoon; Kemper, Jongsook Kim.

Mol Endocrinol; 21(11): 2698-712, 2007 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17636037

14.

RORα2 requires LSD1 to enhance tumor progression in breast cancer.

Kim, Kyeongkyu; Lee, Ji Min; Yu, Young Suk; Kim, Hyunkyung; Nam, Hye Jin; Moon, Hyeong-Gon; Noh, Dong-Young; Kim, Keun Il; Fang, Sungsoon; Baek, Sung Hee.

Sci Rep; 7(1): 11994, 2017 Sep 20.

Artigo em Inglês | MEDLINE | ID: mdl-28931919

15.

RORα controls hepatic lipid homeostasis via negative regulation of PPARÎ³ transcriptional network.

Kim, Kyeongkyu; Boo, Kyungjin; Yu, Young Suk; Oh, Se Kyu; Kim, Hyunkyung; Jeon, Yoon; Bhin, Jinhyuk; Hwang, Daehee; Kim, Keun Il; Lee, Jun-Su; Im, Seung-Soon; Yoon, Seul Gi; Kim, Il Yong; Seong, Je Kyung; Lee, Ho; Fang, Sungsoon; Baek, Sung Hee.

Nat Commun; 8(1): 162, 2017 07 31.

Artigo em Inglês | MEDLINE | ID: mdl-28757615

16.

Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease.

Kim, Sun Gi; Kim, Byung Kwon; Kim, Kyumin; Fang, Sungsoon.

Endocrinol Metab (Seoul); 31(4): 500-504, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-28029021

17.

ERRÎ³ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive ß Cells.

Yoshihara, Eiji; Wei, Zong; Lin, Chun Shi; Fang, Sungsoon; Ahmadian, Maryam; Kida, Yasuyuki; Tseng, Tiffany; Dai, Yang; Yu, Ruth T; Liddle, Christopher; Atkins, Annette R; Downes, Michael; Evans, Ronald M.

Cell Metab; 23(4): 622-34, 2016 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-27076077

18.

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

Fang, Sungsoon; Suh, Jae Myoung; Reilly, Shannon M; Yu, Elizabeth; Osborn, Olivia; Lackey, Denise; Yoshihara, Eiji; Perino, Alessia; Jacinto, Sandra; Lukasheva, Yelizaveta; Atkins, Annette R; Khvat, Alexander; Schnabl, Bernd; Yu, Ruth T; Brenner, David A; Coulter, Sally; Liddle, Christopher; Schoonjans, Kristina; Olefsky, Jerrold M; Saltiel, Alan R; Downes, Michael; Evans, Ronald M.

Nat Med; 21(2): 159-65, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25559344

19.

Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.

Kanamaluru, Deepthi; Xiao, Zhen; Fang, Sungsoon; Choi, Sung-E; Kim, Dong-Hyun; Veenstra, Timothy D; Kemper, Jongsook Kim.

Mol Cell Biol; 31(7): 1540-50, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21262773

20.

Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.

Miao, Ji; Fang, Sungsoon; Lee, Jiyoung; Comstock, Clay; Knudsen, Karen E; Kemper, Jongsook Kim.

Mol Cell Biol; 29(23): 6170-81, 2009 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-19805516

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