Pesquisa | Biblioteca Virtual em Saúde

1.

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

Varela, Ignacio; Tarpey, Patrick; Raine, Keiran; Huang, Dachuan; Ong, Choon Kiat; Stephens, Philip; Davies, Helen; Jones, David; Lin, Meng-Lay; Teague, Jon; Bignell, Graham; Butler, Adam; Cho, Juok; Dalgliesh, Gillian L; Galappaththige, Danushka; Greenman, Chris; Hardy, Claire; Jia, Mingming; Latimer, Calli; Lau, King Wai; Marshall, John; McLaren, Stuart; Menzies, Andrew; Mudie, Laura; Stebbings, Lucy; Largaespada, David A; Wessels, L F A; Richard, Stephane; Kahnoski, Richard J; Anema, John; Tuveson, David A; Perez-Mancera, Pedro A; Mustonen, Ville; Fischer, Andrej; Adams, David J; Rust, Alistair; Chan-on, Waraporn; Subimerb, Chutima; Dykema, Karl; Furge, Kyle; Campbell, Peter J; Teh, Bin Tean; Stratton, Michael R; Futreal, P Andrew.

Nature; 469(7331): 539-42, 2011 Jan 27.

Artigo em Inglês | MEDLINE | ID: mdl-21248752

2.

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

Dalgliesh, Gillian L; Furge, Kyle; Greenman, Chris; Chen, Lina; Bignell, Graham; Butler, Adam; Davies, Helen; Edkins, Sarah; Hardy, Claire; Latimer, Calli; Teague, Jon; Andrews, Jenny; Barthorpe, Syd; Beare, Dave; Buck, Gemma; Campbell, Peter J; Forbes, Simon; Jia, Mingming; Jones, David; Knott, Henry; Kok, Chai Yin; Lau, King Wai; Leroy, Catherine; Lin, Meng-Lay; McBride, David J; Maddison, Mark; Maguire, Simon; McLay, Kirsten; Menzies, Andrew; Mironenko, Tatiana; Mulderrig, Lee; Mudie, Laura; O'Meara, Sarah; Pleasance, Erin; Rajasingham, Arjunan; Shepherd, Rebecca; Smith, Raffaella; Stebbings, Lucy; Stephens, Philip; Tang, Gurpreet; Tarpey, Patrick S; Turrell, Kelly; Dykema, Karl J; Khoo, Sok Kean; Petillo, David; Wondergem, Bill; Anema, John; Kahnoski, Richard J; Teh, Bin Tean; Stratton, Michael R.

Nature; 463(7279): 360-3, 2010 Jan 21.

Artigo em Inglês | MEDLINE | ID: mdl-20054297

3.

Chromosome instability drives phenotypic switching to metastasis.

Gao, ChongFeng; Su, Yanli; Koeman, Julie; Haak, Elizabeth; Dykema, Karl; Essenberg, Curt; Hudson, Eric; Petillo, David; Khoo, Sok Kean; Vande Woude, George F.

Proc Natl Acad Sci U S A; 113(51): 14793-14798, 2016 12 20.

Artigo em Inglês | MEDLINE | ID: mdl-27930335

4.

Disruption of tubular Flcn expression as a mouse model for renal tumor induction.

Chen, Jindong; Huang, Dachuan; Rubera, Isabelle; Futami, Kunihiko; Wang, Pengfei; Zickert, Peter; Khoo, Sok-Kean; Dykema, Karl; Zhao, Ping; Petillo, David; Cao, Brian; Zhang, Zhongfa; Si, Shuhui; Schoen, Susan R; Yang, Ximing J; Zhou, Ming; Xiao, Guang-Qian; Wu, Guan; Nordenskjöld, Magnus; Tauc, Michel; Williams, Bart O; Furge, Kyle A; Teh, Bin Tean.

Kidney Int; 88(5): 1057-69, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26083655

5.

Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling.

Foley, Jessica M; Scholten, Donald J; Monks, Noel R; Cherba, David; Monsma, David J; Davidson, Paula; Dylewski, Dawna; Dykema, Karl; Winn, Mary E; Steensma, Matthew R.

J Transl Med; 13: 110, 2015 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-25889105

6.

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations.

Peacock, Jacqueline D; Dykema, Karl J; Toriello, Helga V; Mooney, Marie R; Scholten, Donald J; Winn, Mary E; Borgman, Andrew; Duesbery, Nicholas S; Hiemenga, Judith A; Liu, Cong; Campbell, Stacey; Nickoloff, Brian P; Williams, Bart O; Steensma, Matthew.

Am J Med Genet A; 167(7): 1429-35, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-25808193

7.

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.

Looyenga, Brendan D; Furge, Kyle A; Dykema, Karl J; Koeman, Julie; Swiatek, Pamela J; Giordano, Thomas J; West, Andrew B; Resau, James H; Teh, Bin T; MacKeigan, Jeffrey P.

Proc Natl Acad Sci U S A; 108(4): 1439-44, 2011 Jan 25.

Artigo em Inglês | MEDLINE | ID: mdl-21220347

8.

Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.

Gerlinger, Marco; Santos, Claudio R; Spencer-Dene, Bradley; Martinez, Pierre; Endesfelder, David; Burrell, Rebecca A; Vetter, Marcus; Jiang, Ming; Saunders, Rebecca E; Kelly, Gavin; Dykema, Karl; Rioux-Leclercq, Nathalie; Stamp, Gordon; Patard, Jean Jacques; Larkin, James; Howell, Michael; Swanton, Charles.

J Pathol; 227(2): 146-56, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22362593

9.

Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer.

Graveel, Carrie R; DeGroot, Jack D; Su, Yanli; Koeman, Julie; Dykema, Karl; Leung, Samuel; Snider, Jacqueline; Davies, Sherri R; Swiatek, Pamela J; Cottingham, Sandra; Watson, Mark A; Ellis, Matthew J; Sigler, Robert E; Furge, Kyle A; Vande Woude, George F.

Proc Natl Acad Sci U S A; 106(31): 12909-14, 2009 Aug 04.

Artigo em Inglês | MEDLINE | ID: mdl-19567831

10.

Evaluation of sex-specific gene expression in archived dried blood spots (DBS).

Resau, James H; Ho, Nhan T; Dykema, Karl; Faber, Matthew S; Busik, Julia V; Nickolov, Radoslav Z; Furge, Kyle A; Paneth, Nigel; Jewell, Scott; Khoo, Sok Kean.

Int J Mol Sci; 13(8): 9599-608, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22949818

11.

Molecular classification of breast phyllodes tumors: validation of the histologic grading scheme and insights into malignant progression.

Ang, Mei Kim; Ooi, Aik Seng; Thike, Aye Aye; Tan, Patrick; Zhang, Zhongfa; Dykema, Karl; Furge, Kyle; Teh, Bin Tean; Tan, Puay Hoon.

Breast Cancer Res Treat; 129(2): 319-29, 2011 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-20945089

12.

Acquiring genome-wide gene expression profiles in Guthrie card blood spots using microarrays.

Khoo, Sok Kean; Dykema, Karl; Vadlapatla, Naga Manjari; LaHaie, David; Valle, Saul; Satterthwaite, David; Ramirez, Sara Angeline; Carruthers, Janell Alee; Haak, Peterson Todd; Resau, James Howard.

Pathol Int; 61(1): 1-6, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21166936

13.

Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated EGLN2-mediated [corrected] oxygen-sensing response.

Koeman, Julie M; Russell, Ryan C; Tan, Min-Han; Petillo, David; Westphal, Michael; Koelzer, Katherine; Metcalf, Julie L; Zhang, Zhongfa; Matsuda, Daisuke; Dykema, Karl J; Houseman, Heather L; Kort, Eric J; Furge, Laura L; Kahnoski, Richard J; Richard, Stéphane; Vieillefond, Annick; Swiatek, Pamela J; Teh, Bin Tean; Ohh, Michael; Furge, Kyle A.

PLoS Genet; 4(9): e1000176, 2008 Sep 05.

Artigo em Inglês | MEDLINE | ID: mdl-18773095

14.

Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.

Zang, Zhi Jiang; Ong, Choon Kiat; Cutcutache, Ioana; Yu, Willie; Zhang, Shen Li; Huang, Dachuan; Ler, Lian Dee; Dykema, Karl; Gan, Anna; Tao, Jiong; Lim, Siyu; Liu, Yujing; Futreal, P Andrew; Grabsch, Heike; Furge, Kyle A; Goh, Liang Kee; Rozen, Steve; Teh, Bin Tean; Tan, Patrick.

Cancer Res; 71(1): 29-39, 2011 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-21097718

15.

Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy.

Schaeffer, Edward M; Guzzo, Thomas J; Furge, Kyle A; Netto, George; Westphal, Michael; Dykema, Karl; Yang, Ximing; Zhou, Ming; Teh, Bin Tean; Pavlovich, Christian P.

BJU Int; 106(1): 62-5, 2010 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-20002663

16.

Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma.

Furge, Kyle A; Chen, Jindong; Koeman, Julie; Swiatek, Pamela; Dykema, Karl; Lucin, Kseniji; Kahnoski, Richard; Yang, Ximing J; Teh, Bin Tean.

Cancer Res; 67(7): 3171-6, 2007 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-17409424

17.

Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia.

McKay, Erin C; Beck, John S; Khoo, Sok Kean; Dykema, Karl J; Cottingham, Sandra L; Winn, Mary E; Paulson, Henry L; Lieberman, Andrew P; Counts, Scott E.

J Neuropathol Exp Neurol; 78(5): 436-452, 2019 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-30990880

18.

A highly invasive human glioblastoma pre-clinical model for testing therapeutics.

Xie, Qian; Thompson, Ryan; Hardy, Kim; DeCamp, Lisa; Berghuis, Bree; Sigler, Robert; Knudsen, Beatrice; Cottingham, Sandra; Zhao, Ping; Dykema, Karl; Cao, Brian; Resau, James; Hay, Rick; Vande Woude, George F.

J Transl Med; 6: 77, 2008 Dec 03.

Artigo em Inglês | MEDLINE | ID: mdl-19055779

19.

A Developmental and Molecular View of Formation of Auxin-Induced Nodule-Like Structures in Land Plants.

Hiltenbrand, Ryan; Thomas, Jacklyn; McCarthy, Hannah; Dykema, Karl J; Spurr, Ashley; Newhart, Hamilton; Winn, Mary E; Mukherjee, Arijit.

Front Plant Sci; 7: 1692, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27891144

20.

Comparison of array-based comparative genomic hybridization with gene expression-based regional expression biases to identify genetic abnormalities in hepatocellular carcinoma.

Furge, Kyle A; Dykema, Karl J; Ho, Coral; Chen, Xin.

BMC Genomics; 6: 67, 2005 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-15882461

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