Pesquisa | Biblioteca Virtual em Saúde

1.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

Finan, Brian; Clemmensen, Christoffer; Zhu, Zhimeng; Stemmer, Kerstin; Gauthier, Karine; Müller, Luisa; De Angelis, Meri; Moreth, Kristin; Neff, Frauke; Perez-Tilve, Diego; Fischer, Katrin; Lutter, Dominik; Sánchez-Garrido, Miguel A; Liu, Peng; Tuckermann, Jan; Malehmir, Mohsen; Healy, Marc E; Weber, Achim; Heikenwalder, Mathias; Jastroch, Martin; Kleinert, Maximilian; Jall, Sigrid; Brandt, Sara; Flamant, Frédéric; Schramm, Karl-Werner; Biebermann, Heike; Döring, Yvonne; Weber, Christian; Habegger, Kirk M; Keuper, Michaela; Gelfanov, Vasily; Liu, Fa; Köhrle, Josef; Rozman, Jan; Fuchs, Helmut; Gailus-Durner, Valerie; Hrabe de Angelis, Martin; Hofmann, Susanna M; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard; Müller, Timo D.

Cell; 167(3): 843-857.e14, 2016 Oct 20.

Artigo em Inglês | MEDLINE | ID: mdl-27720451

2.

Comprehensive analysis of nine monoamines and metabolites in small amounts of peripheral murine (C57Bl/6 J) tissues.

Nagler, Joachim; Schriever, Sonja C; De Angelis, Meri; Pfluger, Paul T; Schramm, Karl-Werner.

Biomed Chromatogr; 32(4)2018 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-29166705

3.

Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.

Rudolph, Dale A; Alcazar, Jesus; Ameriks, Michael K; Anton, Ana Belen; Ao, Hong; Bonaventure, Pascal; Carruthers, Nicholas I; Chrovian, Christa C; De Angelis, Meri; Lord, Brian; Rech, Jason C; Wang, Qi; Bhattacharya, Anindya; Andres, Jose Ignacio; Letavic, Michael A.

Bioorg Med Chem Lett; 25(16): 3157-63, 2015 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-26099534

4.

Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors.

Andrés, José-Ignacio; Buijnsters, Peter; De Angelis, Meri; Langlois, Xavier; Rombouts, Frederik; Trabanco, Andrés A; Vanhoof, Greet.

Bioorg Med Chem Lett; 23(3): 785-90, 2013 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-23260348

5.

Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.

Rakov, Helena; De Angelis, Meri; Renko, Kostja; Hönes, Georg Sebastian; Zwanziger, Denise; Moeller, Lars Christian; Schramm, Karl-Werner; Führer, Dagmar.

Thyroid; 2019 Sep 26.

Artigo em Inglês | MEDLINE | ID: mdl-31441387

6.

Determination of thyroid hormones in placenta using isotope-dilution liquid chromatography quadrupole time-of-flight mass spectrometry.

Li, Zhong-Min; Giesert, Florian; Vogt-Weisenhorn, Daniela; Main, Katharina Maria; Skakkebæk, Niels Erik; Kiviranta, Hannu; Toppari, Jorma; Feldt-Rasmussen, Ulla; Shen, Heqing; Schramm, Karl-Werner; De Angelis, Meri.

J Chromatogr A; 1534: 85-92, 2018 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-29307529

7.

Association of In Utero Persistent Organic Pollutant Exposure With Placental Thyroid Hormones.

Li, Zhong-Min; Hernandez-Moreno, David; Main, Katharina Maria; Skakkebæk, Niels Erik; Kiviranta, Hannu; Toppari, Jorma; Feldt-Rasmussen, Ulla; Shen, Heqing; Schramm, Karl-Werner; De Angelis, Meri.

Endocrinology; 159(10): 3473-3481, 2018 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-30059991

8.

Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.

Pfuhlmann, Katrin; Schriever, Sonja C; Baumann, Peter; Kabra, Dhiraj G; Harrison, Luke; Mazibuko-Mbeje, Sithandiwe E; Contreras, Raian E; Kyriakou, Eleni; Simonds, Stephanie E; Tiganis, Tony; Cowley, Michael A; Woods, Stephen C; Jastroch, Martin; Clemmensen, Christoffer; De Angelis, Meri; Schramm, Karl-Werner; Sattler, Michael; Messias, Ana C; Tschöp, Matthias H; Pfluger, Paul T.

Diabetes; 67(11): 2456-2465, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30158241

9.

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.

Kyriakou, Eleni; Schmidt, Stefanie; Dodd, Garron T; Pfuhlmann, Katrin; Simonds, Stephanie E; Lenhart, Dominik; Geerlof, Arie; Schriever, Sonja C; De Angelis, Meri; Schramm, Karl-Werner; Plettenburg, Oliver; Cowley, Michael A; Tiganis, Tony; Tschöp, Matthias H; Pfluger, Paul T; Sattler, Michael; Messias, Ana C.

J Med Chem; 61(24): 11144-11157, 2018 12 27.

Artigo em Inglês | MEDLINE | ID: mdl-30525586

10.

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

Letavic, Michael A; Savall, Brad M; Allison, Brett D; Aluisio, Leah; Andres, Jose Ignacio; De Angelis, Meri; Ao, Hong; Beauchamp, Derek A; Bonaventure, Pascal; Bryant, Stewart; Carruthers, Nicholas I; Ceusters, Marc; Coe, Kevin J; Dvorak, Curt A; Fraser, Ian C; Gelin, Christine F; Koudriakova, Tatiana; Liang, Jimmy; Lord, Brian; Lovenberg, Timothy W; Otieno, Monicah A; Schoetens, Freddy; Swanson, Devin M; Wang, Qi; Wickenden, Alan D; Bhattacharya, Anindya.

J Med Chem; 60(11): 4559-4572, 2017 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-28493698

11.

Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.

Gemma, Sandra; Gabellieri, Emanuele; Huleatt, Paul; Fattorusso, Caterina; Borriello, Marianna; Catalanotti, Bruno; Butini, Stefania; De Angelis, Meri; Novellino, Ettore; Nacci, Vito; Belinskaya, Tatyana; Saxena, Ashima; Campiani, Giuseppe.

J Med Chem; 49(11): 3421-5, 2006 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-16722663

12.

Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography-mass spectrometry method.

De Angelis, Meri; Giesert, Florian; Finan, Brian; Clemmensen, Christoffer; Müller, Timo D; Vogt-Weisenhorn, Daniela; Tschöp, Matthias H; Schramm, Karl-Werner.

J Chromatogr B Analyt Technol Biomed Life Sci; 1033-1034: 413-420, 2016 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-27649501

13.

Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.

Swanson, Devin M; Savall, Brad M; Coe, Kevin J; Schoetens, Freddy; Koudriakova, Tatiana; Skaptason, Judith; Wall, Jessica; Rech, Jason; Deng, Xiahou; De Angelis, Meri; Everson, Anita; Lord, Brian; Wang, Qi; Ao, Hong; Scott, Brian; Sepassi, Kia; Lovenberg, Timothy W; Carruthers, Nicholas I; Bhattacharya, Anindya; Letavic, Michael A.

J Med Chem; 59(18): 8535-48, 2016 09 22.

Artigo em Inglês | MEDLINE | ID: mdl-27548392

14.

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates.

Ory, Dieter; Celen, Sofie; Gijsbers, Rik; Van Den Haute, Chris; Postnov, Andrey; Koole, Michel; Vandeputte, Caroline; Andrés, José-Ignacio; Alcazar, Jesus; De Angelis, Meri; Langlois, Xavier; Bhattacharya, Anindya; Schmidt, Mark; Letavic, Michael A; Vanduffel, Wim; Van Laere, Koen; Verbruggen, Alfons; Debyser, Zeger; Bormans, Guy.

J Nucl Med; 57(9): 1436-41, 2016 09.

Artigo em Inglês | MEDLINE | ID: mdl-27199364

15.

Indazole estrogens: highly selective ligands for the estrogen receptor beta.

De Angelis, Meri; Stossi, Fabio; Carlson, Kathryn A; Katzenellenbogen, Benita S; Katzenellenbogen, John A.

J Med Chem; 48(4): 1132-44, 2005 Feb 24.

Artigo em Inglês | MEDLINE | ID: mdl-15715479

16.

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.

Fattorusso, Caterina; Gemma, Sandra; Butini, Stefania; Huleatt, Paul; Catalanotti, Bruno; Persico, Marco; De Angelis, Meri; Fiorini, Isabella; Nacci, Vito; Ramunno, Anna; Rodriquez, Manuela; Greco, Giovanni; Novellino, Ettore; Bergamini, Alberto; Marini, Stefano; Coletta, Massimo; Maga, Giovanni; Spadari, Silvio; Campiani, Giuseppe.

J Med Chem; 48(23): 7153-65, 2005 Nov 17.

Artigo em Inglês | MEDLINE | ID: mdl-16279773

17.

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists.

Savall, Brad M; Wu, Duncan; De Angelis, Meri; Carruthers, Nicholas I; Ao, Hong; Wang, Qi; Lord, Brian; Bhattacharya, Anindya; Letavic, Michael A.

ACS Med Chem Lett; 6(6): 671-6, 2015 Jun 11.

Artigo em Inglês | MEDLINE | ID: mdl-26101572

18.

Synthesis and biological evaluation of carbon-11 and fluorine-18 labeled tracers for in vivo visualization of PDE10A.

Ooms, Maarten; Celen, Sofie; Koole, Michel; Langlois, Xavier; Schmidt, Mark; De Angelis, Meri; Andrés, José Ignacio; Verbruggen, Alfons; Van Laere, Koen; Bormans, Guy.

Nucl Med Biol; 41(8): 695-704, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-25002365

19.

Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement.

Buijnsters, Peter; De Angelis, Meri; Langlois, Xavier; Rombouts, Frederik J R; Sanderson, Wendy; Tresadern, Gary; Ritchie, Alison; Trabanco, Andrés A; VanHoof, Greet; Roosbroeck, Yves Van; Andrés, José-Ignacio.

ACS Med Chem Lett; 5(9): 1049-53, 2014 Sep 11.

Artigo em Inglês | MEDLINE | ID: mdl-25221665

20.

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465.