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Risk of Early Adverse Events After Clopidogrel Discontinuation in Patients Undergoing Short-Term Dual Antiplatelet Therapy: An Individual Participant Data Analysis

Piccolo, Raffaele; Feres, Fausto; Abizaid, Alexandre; Gilard, Martine; Morice, Marie-Claude; Hong, Myeong-Ki; Kim, Hyo-Soo; Colombo, Antonio; Bhatt, Deepak L; Palmerini, Tullio; Stone, Gregg W; Windecker, Stephan; Valgimigli, Marco.
JACC Cardiovasc Interv; 10(16): 1621-1630, 2017. ilus, tab
Artigo em Inglês | Sec. Est. Saúde SP | 2017 | ID: ses-37350
Resumo: OBJECTIVES:The study sought to evaluate the presence of a clinically relevant rebound phenomenon after dual antiplatelet therapy (DAPT) discontinuation in randomized trials.BACKGROUND:It is currently unknown whether clopidogrel discontinuation after short-term DAPT is associated with an early hazard of ischemic events.METHODS:The authors performed an individual participant data analysis and aggregate meta-analysis. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as the composite of cardiac death, myocardial infarction (MI), or stroke. (AU)
Biblioteca responsável: BR79.1
Localização: BR79.1