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Evaluation of a daily dose of 25 micrograms vitamin K1 to prevent vitamin K deficiency in breast-fed infants.

Cornelissen, E A; Kollée, L A; van Lith, T G; Motohara, K; Monnens, L A.
J Pediatr Gastroenterol Nutr; 16(3): 301-5, 1993 Apr.
Artigo em Inglês | MEDLINE | Abr 1993 | ID: mdl-8492260
Resumo: Vitamin K prophylaxis is recommended to prevent the hazard of hemorrhage caused by vitamin K deficiency in young infants. A single administration after birth seems inadequate to completely prevent late haemorrhagic disease in breast-fed infants. The preventive effect of a daily oral dose of 25 micrograms vitamin K1, which is comparable to about half the dose ingested by formula-fed infants, was evaluated in 58 breast-fed infants. No clinical or biochemical signs of vitamin K deficiency occurred; PIVKA-II was not detectable, and vitamin K1 concentrations were moderately elevated. Vitamin K1 levels were negatively correlated with the number of hours elapsed since the most recent gift. Twenty to 28 h after the administration, median (P10-P90) levels were 1,262 (267-4,328), 1,072 (293-3,427), and 882 (329-2,070) pg/ml at 4, 8, and 12 weeks of age, respectively. Vitamin K1 levels in formula-fed infants (n = 10) were around 7,000 pg/ml. In conclusion, daily supplementation of 25 micrograms vitamin K1 can be recommended for breast-fed infants to prevent vitamin K deficiency beyond the neonatal period.