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Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth.

Flood, Veronica H; Galderisi, Faith C; Lowas, Stefanie R; Kendrick, Angela; Boshkov, Lynn K.
Pediatr Blood Cancer; 50(5): 1075-7, 2008 May.
Artigo em Inglês | MEDLINE | 2008 | ID: mdl-17957759
Resumo: Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.