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Atenção Primária à Saúde

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Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns.

Eshleman, Susan H; Hoover, Donald R; Chen, Shu; Hudelson, Sarah E; Guay, Laura A; Mwatha, Anthony; Fiscus, Susan A; Mmiro, Francis; Musoke, Philippa; Jackson, J Brooks; Kumwenda, Newton; Taha, Taha.
AIDS; 19(18): 2167-9, 2005 Dec 02.
Artigo em Inglês | MEDLINE | Nov 2005 | ID: mdl-16284468
Resumo: The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants who were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).