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Structural insights on the role of antibodies in HIV-1 vaccine and therapy.

West, Anthony P; Scharf, Louise; Scheid, Johannes F; Klein, Florian; Bjorkman, Pamela J; Nussenzweig, Michel C.
Cell; 156(4): 633-48, 2014 Feb 13.
Article in English | MEDLINE | Feb 2014 | ID: mdl-24529371
Abstract: Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.