Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
West, Anthony P; Scharf, Louise; Scheid, Johannes F; Klein, Florian; Bjorkman, Pamela J; Nussenzweig, Michel C.
; 156(4): 633-48, 2014 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-24529371
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.
HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage.
Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers.
Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.
Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies.
Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans.
Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies.