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L-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys.

Soghomonian, J J; Pedneault, S; Blanchet, P J; Goulet, M; Di Paolo, T; Bédard, P J.
Brain Res Mol Brain Res; 39(1-2): 237-40, 1996 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-8804732
The effect of dopaminergic denervation, alone or followed by chronic intermittent L-DOPA administration, on the levels of mRNAs encoding for the two isoforms of the GABA-synthesizing enzyme, glutamate decarboxylase (GAD65 and GAD67), were measured by in-situ hybridization in the caudate and putamen of macaque monkeys. When compared to control monkeys, the level of GAD67 mRNA was increased in the putamen and caudate of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. On the other hand, GAD65 mRNA labeling in MPTP-treated monkeys was not significantly different from the controls. In MPTP-treated monkeys that received L-DOPA, a significant increase in both GAD67 and GAD65 mRNA levels was measured in the putamen when compared to control or MPTP-treated monkeys. The results suggest that the dyskinetic effect of L-DOPA is paralleled by an increased GABAergic activity in the striatum.
Selo DaSilva