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Neutrophils mitigate the systemic host response during endotoxemia in mice.

van der Meer, Anne Jan; Ding, Chao; Hoogendijk, Arie Johan; de Vos, Alex F; Boon, Louis; Zeerleder, Sacha S; van der Poll, Tom.
Immunology; 2018 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-30472736
Recent studies have suggested that neutrophils can exert anti-inflammatory effects. To determine the role of neutrophils in the acute response to lipopolysaccharide (LPS), component of the gram-negative bacterial cell wall, we challenged neutrophil depleted and control mice with LPS and analyzed the plasma concentrations of biomarkers indicative of the cytokine and chemokine network, activation of coagulation and the vascular endothelium, and cellular injury. We here show that neutrophils serve an anti-inflammatory role upon LPS administration, as reflected by sustained elevations in multiple cytokines and chemokines, and enhanced release of nucleosomes in mice depleted of neutrophils, compared to control mice. This article is protected by copyright. All rights reserved.
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