MZB1 folding and unfolding the role of IgA.
Suzuki, Keiichiro; Vogelzang, Alexis; Fagarasan, Sidonia.
Proc Natl Acad Sci U S A
; 116(27): 13163-13165, 2019 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-31201222
MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation.
Porque a angústia é necessária
MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.
Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and ß1-integrin function.
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