CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.
Suan, Dan; Kräutler, Nike J; Maag, Jesper L V; Butt, Danyal; Bourne, Katherine; Hermes, Jana R; Avery, Danielle T; Young, Clara; Statham, Aaron; Elliott, Michael; Dinger, Marcel E; Basten, Antony; Tangye, Stuart G; Brink, Robert.
; 47(6): 1142-1153.e4, 2017 12 19.
Artigo em Inglês | MEDLINE | ID: mdl-29262350
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation.
Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells.
BLIMP-1 is insufficient to induce antibody secretion in the absence of IRF4 in DT40 cells.
Plasma cells require autophagy for sustainable immunoglobulin production.
Hobit- and Blimp-1-driven CD4<sup>+</sup> tissue-resident memory T cells control chronic intestinal inflammation.
Mcl-1 is essential for the survival of plasma cells.
Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and ß1-integrin function.
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile.
PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids.