Docosahexaenoic acid lowers cardiac mitochondrial enzyme activity by replacing linoleic acid in the phospholipidome.
Sullivan, E Madison; Pennington, Edward Ross; Sparagna, Genevieve C; Torres, Maria J; Neufer, P Darrell; Harris, Mitchel; Washington, James; Anderson, Ethan J; Zeczycki, Tonya N; Brown, David A; Shaikh, Saame Raza.
J Biol Chem
; 293(2): 466-483, 2018 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-29162722
The phospholipase iPLA<sub>2</sub>Î³ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.
Increasing mitochondrial membrane phospholipid content lowers the enzymatic activity of electron transport complexes.
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Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy.
A simulation study on the constancy of cardiac energy metabolites during workload transition.