IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.
Jandl, Christoph; Liu, Sue M; Cañete, Pablo F; Warren, Joanna; Hughes, William E; Vogelzang, Alexis; Webster, Kylie; Craig, Maria E; Uzel, Gulbu; Dent, Alexander; Stepensky, Polina; Keller, Bärbel; Warnatz, Klaus; Sprent, Jonathan; King, Cecile.
; 8: 14647, 2017 03 17.
Artigo em Inglês | MEDLINE | ID: mdl-28303891
IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses.
Suppression by T<sub>FR</sub> cells leads to durable and selective inhibition of B cell effector function.
Interleukin-22 promotes phagolysosomal fusion to induce protection against <i>Salmonella enterica</i> Typhimurium in human epithelial cells.
IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells.
CTL-Promoting Effects of IL-21 Counteract Murine Lupus in the ParentâF1 Graft-versus-Host Disease Model.
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PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells.
Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.