The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Moroishi, Toshiro; Hayashi, Tomoko; Pan, Wei-Wei; Fujita, Yu; Holt, Matthew V; Qin, Jun; Carson, Dennis A; Guan, Kun-Liang.
; 167(6): 1525-1539.e17, 2016 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-27912060
YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKÉ-mediated phosphorylation.
Hippo/Mst signalling couples metabolic state and immune function of CD8α<sup>+</sup> dendritic cells.
The NDR/LATS protein kinases in immunology and cancer biology.
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.
The interplay between centrosomes and the Hippo tumor suppressor pathway.
Down-regulation of LATS kinases alters p53 to promote cell migration.
Cytokinesis failure triggers hippo tumor suppressor pathway activation.
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.