iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.
Luo, Wei-Wei; Li, Shu; Li, Chen; Lian, Huan; Yang, Qing; Zhong, Bo; Shu, Hong-Bing.
; 17(9): 1057-66, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27428826
Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.
The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination.
Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation.
Complement and its receptors: new insights into human disease.
Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?
Innate immune response in astrocytes infected with herpes simplex virus 1.
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage.
Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment.